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. 1979 Dec;16(6):855–857. doi: 10.1128/aac.16.6.855

Chlorhexidine as an effective agent against Chlamydia trachomatis in vitro and in vivo.

I T Nisbet, D M Graham, P E Spicer, G J Tibbs
PMCID: PMC352965  PMID: 533265

Abstract

In a small field trial, chlorhexidine (50 micrograms/ml) was as effective against clinical trachoma as topical tetracyclines or oral co-trimoxazole; in vitro, 2.5 micrograms/ml was chlamydicidal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DAVIES G. E., FRANCIS J., MARTIN A. R., ROSE F. L., SWAIN G. 1:6-Di-4'-chlorophenyldiguanidohexane (hibitane); laboratory investigation of a new antibacterial agent of high potency. Br J Pharmacol Chemother. 1954 Jun;9(2):192–196. doi: 10.1111/j.1476-5381.1954.tb00840.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Dawson C. R., Daghfous T., Messadi M., Hoshiwara I., Vastine D. W., Yoneda C., Schacter J. Severe endemic trachoma in tunisia. II. A controlled therapy trial of topically applied chlortetracycline and erythromycin. Arch Ophthalmol. 1974 Sep;92(3):198–203. doi: 10.1001/archopht.1974.01010010206003. [DOI] [PubMed] [Google Scholar]
  3. Dawson C. R., Hanna L., Jawetz E. Controlled treatment trials of trachoma in American Indian children. Lancet. 1967 Nov 4;2(7523):961–964. doi: 10.1016/s0140-6736(67)90796-9. [DOI] [PubMed] [Google Scholar]
  4. Dawson C. R., Hanna L., Wood T. R., Coleman V., Briones O. C., Jawetz E. Controlled trials with trisulfapyrimidines in the treatment of chronic trachoma. J Infect Dis. 1969 Jun;119(6):581–590. doi: 10.1093/infdis/119.6.581. [DOI] [PubMed] [Google Scholar]
  5. Graham D. M., Nichols R. L., Mann I. Studies on the epidemiology, microbiology and immunology of trachoma among children at three centres in Western Australia. Med J Aust. 1973 Aug 25;2(8):353–360. doi: 10.5694/j.1326-5377.1973.tb115111.x. [DOI] [PubMed] [Google Scholar]
  6. Graham D. M., Praszkier J., Rollo D. J. Lymphogranuloma venereum in Australia. 1. Clinical aspects of the disease and isolation and identification of the causal agent from a patient in Melbourne. Med J Aust. 1974 Aug 17;2(7):239–243. doi: 10.5694/j.1326-5377.1974.tb70740.x. [DOI] [PubMed] [Google Scholar]
  7. Hardy D., Surman P. G., Howarth W. H. The cytology of conjunctival smears from aboriginal school children at Yalata, South Australia. Am J Ophthalmol. 1967 May;63(5 Suppl):1538–1540. [PubMed] [Google Scholar]
  8. Hoshiwara I., Ostler H. B., Hanna L., Cignetti F., Coleman V. R., Jawetz E. Doxycycline treatment of chronic trachoma. JAMA. 1973 Apr 9;224(2):220–223. [PubMed] [Google Scholar]
  9. Löe H., Schiott C. R. The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man. J Periodontal Res. 1970;5(2):79–83. doi: 10.1111/j.1600-0765.1970.tb00696.x. [DOI] [PubMed] [Google Scholar]
  10. REEVE P., TAVERNE J. Observatios on the growth of trachoma and inclusion blennorrhoea viruses in embryonate eggs. J Hyg (Lond) 1963 Mar;61:67–75. doi: 10.1017/s0022172400020751. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Richmond S. J. The inactivation of Chlamydia trachomatis by chlorhexidine ('Hibitane'). J Antimicrob Chemother. 1977 Sep;3(5):523–525. doi: 10.1093/jac/3.5.523. [DOI] [PubMed] [Google Scholar]

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