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. 1980 Dec;18(6):926–929. doi: 10.1128/aac.18.6.926

R-factor responsible for an outbreak of multiply antibiotic-resistant Klebsiella pneumoniae.

M A Courtney, J R Miller, J Summersgill, J Melo, M J Raff, U N Streips
PMCID: PMC352990  PMID: 7016028

Abstract

Seven serotypes of Klebsiella pneumoniae isolated from different patients demonstrated resistance to the same eight antibiotics. A plasmid carrying resistance determinants to these antibiotics and mercury salts could be transferred in toto to a plasmidless strain of Escherichia coli. All E. coli transconjugants showed the same antibiotic resistance pattern. Digestion with restriction endonucleases yielded patterns that were identical for each of the R-factor transferred from the multiply resistant serotypes. Moreover, deoxyribonucleic acid-deoxyribonucleic acid hybridization demonstrated identity between the probe, pMAC20 (an R-factor from one serotype), and all R-factors isolated from the multiply resistant strains of K. pneumoniae and the E. coli transconjugants tested.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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