Skip to main content
. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Medchemcomm. 2012 Jan 27;3(6):699–709. doi: 10.1039/C2MD00320A

Fig. 6.

Fig. 6

Pyridylthiazole-based ureas potently inhibit phosphorylation of a ROCK substrate MYPT1 in human lung cancer cells. H1299 lung cancer cells were treated with increasing concentrations of (a) 5a, (R)-14f, (S)-14f and (b) 5b and 5d and then tested by Western blot assays for phospho-MYPT1. The ROCK inhibitor Y-27632 was used as positive control (10 µM in both experiments).