Figure 5.

Schematic illustration showing the mechanism by which GAPDH negatively regulates HIV-1 infection. A single copy of each molecule is shown for simplicity. As described in detail elsewhere [20,26,27], a Pr55^gag/p160^gag-pol/viral RNA complex interacts with a tRNA^Lys3/LysRS complex. Although the actual conformation of the Pr55^gag/p160^gag-pol/viral RNA complex is still unclear, findings of this study suggest that GAPDH and tRNA^Lys3/LysRS complex may compete with each other for interaction with the binding site within Pr55^gag and p160gag-pol.