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. 1979 Feb;29(2):789–793. doi: 10.1128/jvi.29.2.789-793.1979

Nucleotide sequence analysis of two simian virus 40 mutants with deletions in the late region of the genome.

R Contreras, C Cole, P Berg, W Fiers
PMCID: PMC353212  PMID: 219259

Abstract

Two mutants of simian virus 40, dl-1261 and dl-1262, have deletions that map between coordinated 0.90 and 0.95 (Cole et al., J. Virol 24:277--294, 1977). Both affect the structure of the two minor proteins VP2 and VP3. The precise location and size of the deletions have now been determined by nucleotide sequence analysis. Mutant dl-1261 is deleted of 54 base pairs, is temperature sensitive for the protein defined by the D complementation group, and promotes the synthesis of shorter VP2 and VP3 polypeptides. Mutant dl-1262 is viable irrespective of temperature and has a deletion of 36 base pairs, 23 of which overlap the deletion in dl-1261. Since these mutants produce normal VP1, the deleted regions probably have no function in the splicing of precursor RNA to the VP1 mRNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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