Figure 1.
The Hotelling’s T2 statistics of HIV-1 sequences. There are in total 2917 full genome (> 7000 n.t.) HIV-1 sequences including 2829 nominally normal and 88 nominally hypermutated sequences. The hypermutated sequences are from no. 2830-2917 on the horizontal axis. The filled circles are the nominally normal sequences which are significantly different from the normal HIV-1 population at >> 99.9% confidence levels, thus appear to be hypermutated. The filled triangles are the nominally hypermutated sequences that are significantly different from the normal HIV-1 population at < 50% confidence levels, thus appear to be normal.