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. 1979 Mar;29(3):964–972. doi: 10.1128/jvi.29.3.964-972.1979

Defective retrovirus-like 30S RNA species of rat and mouse cells are infectious if packaged by type C helper virus.

E M Scolnick, W C Vass, R S Howk, P H Duesberg
PMCID: PMC353256  PMID: 221684

Abstract

RNA species with properties of defective retrovirus-like 30S RNA genomes have previously been detected in both rats and mice and in some rat and mouse retroviruses. Using cell lines which express high levels of this retrovirus-like RNA, we formed pseudotypes of the 30S RNAs with helper-independent type C viruses. A pseudotype virus complex containing a mouse 30S subunit was transmitted to rat cells, and a pseudotype virus complex containing a rat 30S subunit was transmitted to bat cells. In other transmission experiments, a rat 30S subunit was isolated in nonproducer bat cells without detectable expression of the helper-independent type C virus used to pseudotype it. The results provide further support for the retrovirus-like nature of the rat 30S subunit and provide evidence which supports the protovirus hypothesis proposed by Temin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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