Intrasplenic immunization with infected hepatocytes: a mouse model for studying protective immunity against malaria pre-erythrocytic stage

In this article, some of the data in table 1 were incorrect. The correct table should be:

Table 1.

Protection induce by repetitive immunization with infected hepatocytes

	Route of injection		No. of mice Infected/Injected1	Protection (%)
Antigen	Priming	Boosting1
–
–	–	–	5/5	0
Irradiated sporozoites3	i.v.	i.v.	0/5	100
Infected hepatocytes4	i.s.5	i.p.	6/12	50
Normal hepatocytes6	i.s.	i.p.	7/7	0
Infected hepatocytes	i.p.	i.p.	7/7	0
Normal hepatocytes	i.p.	i.p.	5/5	0

¹Mice were boosted twice with the antigen 7 days apart.

²Mice were challenged with 3000 P. berghei sporozoites.

³Mice were immunized with 1000 irradiated P. berghei sporozoites.

⁴Infected hepatocytes were obtained after liver biopsy perfusion from mice injected with 106 irradiated P. berghei sporozoites.

⁵Intrasplenic injection.

⁶Normal hepatocytes were obtained after liver biopsy perfusion from normal mice.