Skip to main content
NCBI home page
Journal of Virology logoLink to Journal of Virology
. 1979 Jul;31(1):178–183. doi: 10.1128/jvi.31.1.178-183.1979

Virus production and hemoglobin synthesis in variant lines of dimethyl sulfoxide-treated Friend erythroleukemia cells.

D Tsuei, H Haubenstock, R Revoltella, C Friend
PMCID: PMC353433  PMID: 291737

Abstract

Variant Friend erythroleukemia cell clones were compared in regard to their response to dimethyl sulfoxide and in their abilities to synthesize virus and hemoglobin. Clear evidence was obtained that cellular growth is required for virus production. The effects of dimethyl sulfoxide on virus production were not observed in cell lines that were resistant to growth perturbation by the compound. Studies of cell variants that were defective in either hemoglobin or virus synthesis indicate that these activities are independently regulated.

Full text

PDF
178

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DOUGHERTY R. M. Heat inactivation of Rous sarcoma virus. Virology. 1961 Jul;14:371–372. doi: 10.1016/0042-6822(61)90321-x. [DOI] [PubMed] [Google Scholar]
  2. Del Vellano B. C., Nave B., Croker B. P., Lerner R. A., Dixon F. J. The oncornavirus glycoprotein gp69/71: a constituent of the surface of normal and malignant thymocytes. J Exp Med. 1975 Jan 1;141(1):172–187. doi: 10.1084/jem.141.1.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Del Villano B. C., Lerner R. A. Relationship between the oncornavirus gene product gp70 and a major protein secretion of the mouse genital tract. Nature. 1976 Feb 12;259(5543):497–499. doi: 10.1038/259497a0. [DOI] [PubMed] [Google Scholar]
  4. Dube S. K., Pragnell I. B., Kluge N., Gaedicke G., Steinheider G., Ostertag W. Induction of endogenous and of spleen focus-forming viruses during dimethylsulfoxide-induced differentiation of mouse erythroleukemia cells transformed by spleen focus-forming virus. Proc Natl Acad Sci U S A. 1975 May;72(5):1863–1867. doi: 10.1073/pnas.72.5.1863. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ebert P. S., Buell D. N. Viral reverse transcriptase suppression associated with erythroid differentiation of Friend leukemia cells. J Natl Cancer Inst. 1977 Mar;58(3):635–640. doi: 10.1093/jnci/58.3.635. [DOI] [PubMed] [Google Scholar]
  6. Eisen H., Nasi S., Georgopoulos C. P., Arndt-Jovin D., Ostertag W. Surface changes in differentiating Friend erythroleukemic cells in culture. Cell. 1977 Apr;10(4):689–695. doi: 10.1016/0092-8674(77)90102-7. [DOI] [PubMed] [Google Scholar]
  7. Friedman E. A., Schildkraut C. L. Lengthening of the G1 phase is not strictly correlated with differentiation in Friend erythroleukemia cells. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3813–3817. doi: 10.1073/pnas.75.8.3813. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Friend C., Preisler H. D., Scher W. Studies on the control of differentiation of murine virus-induced erythroleukemic cells. Curr Top Dev Biol. 1974;8:81–101. doi: 10.1016/s0070-2153(08)60606-7. [DOI] [PubMed] [Google Scholar]
  9. Friend C., Scher W., Holland J. G., Sato T. Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide. Proc Natl Acad Sci U S A. 1971 Feb;68(2):378–382. doi: 10.1073/pnas.68.2.378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Friend C. The phenomenon of differentiation in murine erythroleukemic cells. Harvey Lect. 1978;72:253–281. [PubMed] [Google Scholar]
  11. GREENWOOD F. C., HUNTER W. M., GLOVER J. S. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem J. 1963 Oct;89:114–123. doi: 10.1042/bj0890114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Harrison P. R., Gilmour R. S., Affara N. A., Conkie D., Paul J. Globin messenger RNA synthesis and processing during haemoglobin induction in Friend cells. II. Evidence for post-transcriptional control in clone 707. Cell Differ. 1974 Jun;3(1):23–30. doi: 10.1016/0045-6039(74)90037-2. [DOI] [PubMed] [Google Scholar]
  13. Ikawa Y., Furusawa M., Sugano H. Erythrocyte membrane-specific antigens in Friend virus-induced leukemia cells. Bibl Haematol. 1973;39:955–967. doi: 10.1159/000427928. [DOI] [PubMed] [Google Scholar]
  14. Leder A., Orkin S., Leder P. Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis. Science. 1975 Nov 28;190(4217):893–894. doi: 10.1126/science.1059262. [DOI] [PubMed] [Google Scholar]
  15. Levy J., Terada M., Rifkind R. A., Marks P. A. Induction of erythroid differentiation by dimethylsulfoxide in cells infected with Friend virus: relationship to the cell cycle. Proc Natl Acad Sci U S A. 1975 Jan;72(1):28–32. doi: 10.1073/pnas.72.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lieberman D., Voloch Z., Aviv H., Nudel U., Revel M. Effects of interferon on hemoglobin synthesis and leukemia virus production in Friend cells. Mol Biol Rep. 1974 Dec;1(8):447–451. doi: 10.1007/BF00360670. [DOI] [PubMed] [Google Scholar]
  17. Luftig R. B., Conscience J. F., Skoultchi A., McMillan P., Revel M., Ruddle F. H. Effect of interferon on dimethyl sulfoxide-stimulated Friend erythroleukemic cells: ultrastructural and biochemical study. J Virol. 1977 Sep;23(3):799–810. doi: 10.1128/jvi.23.3.799-810.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Marchalonis J. J. An enzymic method for the trace iodination of immunoglobulins and other proteins. Biochem J. 1969 Jun;113(2):299–305. doi: 10.1042/bj1130299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Mayer R. J., Smith R. G., Gallo R. C. Reverse transcriptase in normal rhesus monkey placenta. Science. 1974 Sep 6;185(4154):864–867. doi: 10.1126/science.185.4154.864. [DOI] [PubMed] [Google Scholar]
  20. McClintock P. R., Ihle J. N., Joseph D. R. Expression of AKR murine leukemia virus gp71-like and BALB(X) gp-71-like antigens in normal mouse tissues in the absence of overt virus expression. J Exp Med. 1977 Aug 1;146(2):422–434. doi: 10.1084/jem.146.2.422. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. McClintock P. R., Papaconstantinou J. Regulation of hemoglobin synthesis in a murine erythroblastic leukemic cell: the requirement for replication to induce hemoglobin synthesis. Proc Natl Acad Sci U S A. 1974 Nov;71(11):4551–4555. doi: 10.1073/pnas.71.11.4551. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Metzgar R. S., Mohanakumar T., Bolognesi D. P. Relationships between membrane antigens of human leukemic cells and oncogenic RNA virus structural components. J Exp Med. 1976 Jan 1;143(1):47–63. doi: 10.1084/jem.143.1.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Orkin S. H., Harosi F. I., Leder P. Differentiation in erythroleukemic cells and their somatic hybrids. Proc Natl Acad Sci U S A. 1975 Jan;72(1):98–102. doi: 10.1073/pnas.72.1.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Ostertag W., Roesler G., Krieg C. J., Kind J., Cole T., Crozier T., Gaedicke G., Steinheider G., Kluge N., Dube S. Induction of endogenous virus and of thymidine kinase by bromodeoxyuridine in cell cultures transformed by Friend virus. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4980–4985. doi: 10.1073/pnas.71.12.4980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Pragnell I. B., Ostertag W., Paul J. The expression of viral and globin genes during differentiation of the Friend cell. Exp Cell Res. 1977 Sep;108(2):269–278. doi: 10.1016/s0014-4827(77)80034-7. [DOI] [PubMed] [Google Scholar]
  26. Racevskis J., Koch G. Viral protein synthesis in Friend erythroleukemia cell lines. J Virol. 1977 Jan;21(1):328–337. doi: 10.1128/jvi.21.1.328-337.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Rossi G. B., Dolei A., Cioé L., Benedetto A., Matarese G. P., Belardelli F. Inhibition of transcription and translation of globin messenger RNA in dimethyl sulfoxide-stimulated Friend erythroleukemic cells treated with interferon. Proc Natl Acad Sci U S A. 1977 May;74(5):2036–2040. doi: 10.1073/pnas.74.5.2036. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Rovera G., Bonaiuto J. The phenotypes of variant clones of Friend mouse erythroleukemic cells resistant to dimethyl sulfoxide. Cancer Res. 1976 Nov;36(11 Pt 1):4057–4061. [PubMed] [Google Scholar]
  29. Sato T., Friend C., De Harven E. Ultrastructural changes in Friend erythroleukemia cells treated with dimethyl sulfoxide. Cancer Res. 1971 Oct;31(10):1402–1417. [PubMed] [Google Scholar]
  30. Scher W., Friend C. Breakage of DNA and alterations in folded genomes by inducers of differentiation in Friend erythroleukemic cells. Cancer Res. 1978 Mar;38(3):841–849. [PubMed] [Google Scholar]
  31. Scher W., Tsuei D., Sassa S., Price P., Gabelman N., Friend C. Inhibition of dimethyl sulfoxide-stimulated Friend cell erythrodifferentiation by hydrocortisone and other steroids. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3851–3855. doi: 10.1073/pnas.75.8.3851. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Sherton C. C., Dresler S. L., Polonoff E., Webb M. C., Kabat D. Synthesis of murine leukemia virus proteins differentiating Friend erythroleukemia cells. Cancer Res. 1978 May;38(5):1426–1433. [PubMed] [Google Scholar]
  33. Sherton C. C., Evans L. H., Polonoff E., Kabat D. Relationship of Friend murine leukemia virus production to growth and hemoglobin synthesis in cultured erythroleukemia cells. J Virol. 1976 Jul;19(1):118–125. doi: 10.1128/jvi.19.1.118-125.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Swetly P., Ostertag W. Friend virus release and induction of haemoglobin synthesis in erythroleukaemic cells respond differently to interferon. Nature. 1974 Oct 18;251(5476):642–644. doi: 10.1038/251642a0. [DOI] [PubMed] [Google Scholar]
  35. Tabuse Y., Kawamura M., Furusawa M. Induction of haemoglobin synthesis in Friend leukaemia cells without the necessity of mitosis. Differentiation. 1976 Nov 2;7(1):1–5. doi: 10.1111/j.1432-0436.1977.tb01490.x. [DOI] [PubMed] [Google Scholar]
  36. Wecker E., Schimpl A., Hünig T. Expression of MuLV GP71-like antigen in normal mouse spleen cells induced by antigenic stimulation. Nature. 1977 Oct 13;269(5629):598–600. doi: 10.1038/269598a0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES