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. 1979 Jul;31(1):257–260. doi: 10.1128/jvi.31.1.257-260.1979

High-frequency recombination within the gag gene of Rous sarcoma virus.

M Linial, S Brown
PMCID: PMC353442  PMID: 228057

Abstract

We isolated 28 recombinants of Rous sarcoma virus at early (24 h) and late (7 days) times after infection. These recombinants were selected for wild type in the pol and src genes and analyzed for their env and gag phenotypes. We were unable to show strong linkage between any two markers, including two markers within a single gene (gag).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alevy M. C., Vogt P. K. Ts pol mutants of avian sarcoma viruses: mapping and demonstration of single cycle recombinants. Virology. 1978 Jun 1;87(1):21–33. doi: 10.1016/0042-6822(78)90154-x. [DOI] [PubMed] [Google Scholar]
  2. Blair D. G. Genetic recombination between avian leukosis and sarcoma viruses. Experimental variables and the frequencies of recombination. Virology. 1977 Apr;77(2):534–544. doi: 10.1016/0042-6822(77)90479-2. [DOI] [PubMed] [Google Scholar]
  3. Coffin J. M. Structure, replication, and recombination of retrovirus genomes: some unifying hypotheses. J Gen Virol. 1979 Jan;42(1):1–26. doi: 10.1099/0022-1317-42-1-1. [DOI] [PubMed] [Google Scholar]
  4. Eisenman R. N., Vogt V. M. The biosynthesis of oncovirus proteins. Biochim Biophys Acta. 1978 Apr 6;473(3-4):187–239. doi: 10.1016/0304-419x(78)90014-8. [DOI] [PubMed] [Google Scholar]
  5. Hayman M. J., Vogt P. K. Subgroup-specific antigenic determinants of avian RNA tumor virls structural proteins: analysis of virus recombinants. Virology. 1976 Sep;73(2):372–380. doi: 10.1016/0042-6822(76)90398-6. [DOI] [PubMed] [Google Scholar]
  6. Hunter E. The mechanism for genetic recombination in the avian retroviruses. Curr Top Microbiol Immunol. 1978;79:295–309. doi: 10.1007/978-3-642-66853-1_7. [DOI] [PubMed] [Google Scholar]
  7. Joho R. H., Billeter M. A., Weissmann C. Mapping of biological functions on RNA of avian tumor viruses: location of regions required for transformation and determination of host range. Proc Natl Acad Sci U S A. 1975 Dec;72(12):4772–4776. doi: 10.1073/pnas.72.12.4772. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kawai S., Hanafusa H. Genetic recombination with avian tumor virus. Virology. 1972 Jul;49(1):37–44. doi: 10.1016/s0042-6822(72)80005-9. [DOI] [PubMed] [Google Scholar]
  9. Linial M., Brown S., Neiman P. A nonconditional mutant of Rous sarcoma virus containing defective polymerase. Virology. 1978 Jun 1;87(1):130–141. doi: 10.1016/0042-6822(78)90165-4. [DOI] [PubMed] [Google Scholar]
  10. Mason W. S., Friis R. R., Linial M., Vogt P. K. Determination of the defective function in two mutants of Rous sarcoma virus. Virology. 1974 Oct;61(2):559–574. doi: 10.1016/0042-6822(74)90290-6. [DOI] [PubMed] [Google Scholar]
  11. Rettenmier C. W., Hanafusa H. Structural protein markers in the avian oncoviruses. J Virol. 1977 Dec;24(3):850–864. doi: 10.1128/jvi.24.3.850-864.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Reynolds F. H., Jr, Hanson C. A., Aaronson S. A., Stephenson J. R. Type C viral gag gene expression in chicken embryo fibroblasts and avian sarcoma virus-transformed mammalian cells. J Virol. 1977 Jul;23(1):74–79. doi: 10.1128/jvi.23.1.74-79.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Shaikh R., Linial M., Brown S., Sen A., Eisenman R. Recombinant avian oncoviruses. II. Alterations in the gag proteins and evidence for intragenic recombination. Virology. 1979 Jan 30;92(2):463–481. doi: 10.1016/0042-6822(79)90150-8. [DOI] [PubMed] [Google Scholar]
  14. Shaikh R., Linial M., Coffin J., Eisenman R. Recombinant avian oncoviruses. I. Alterations in the precursor to the internal structural proteins. Virology. 1978 Jun 15;87(2):326–338. doi: 10.1016/0042-6822(78)90138-1. [DOI] [PubMed] [Google Scholar]
  15. Vogt P. K. Genetically stable reassortment of markers during mixed infection with avian tumor viruses. Virology. 1971 Dec;46(3):947–952. doi: 10.1016/0042-6822(71)90093-6. [DOI] [PubMed] [Google Scholar]
  16. Wang L., Galehouse D., Mellon P., Duesberg P., Mason W. S., Vogt P. K. Mapping oligonucleotides of Rous sarcoma virus RNA that segregate with polymerase and group-specific antigen markers in recombinants. Proc Natl Acad Sci U S A. 1976 Nov;73(11):3952–3956. doi: 10.1073/pnas.73.11.3952. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wyke J. A., Bell J. G., Beamand J. A. Genetic recombination among temperature-sensitive mutnats of Rous sarcoma virus. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):897–905. doi: 10.1101/sqb.1974.039.01.104. [DOI] [PubMed] [Google Scholar]
  18. Wyke J. A. The selective isolation of temperature-sensitive mutants of Rous sarcoma virus. Virology. 1973 Apr;52(2):587–590. doi: 10.1016/0042-6822(73)90357-7. [DOI] [PubMed] [Google Scholar]

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