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. 1979 Aug;31(2):472–483. doi: 10.1128/jvi.31.2.472-483.1979

Simian virus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum.

M Kress, E May, R Cassingena, P May
PMCID: PMC353470  PMID: 225566

Abstract

In addition to the virus-coded large-T and small-t antigens, two new classes of proteins were immunoprecipitated by anti-simian virus 40 (SV40) tumor serum from extracts of various SV40-transformed cell lines. These were as follows: (i) proteins (termed "super-T proteins") with an Mr higher than that of large-T antigen (86,000), which were found in many SV40-transformed cell lines derived from mouse and rat cells (super-T proteins and large-T antigen appeared to have closely related structures as judged by the Chromobead elution patterns of their methionine-labeled tryptic peptides); (ii) proteins (termed "55K proteins") with an Mr ranging from 50,000 to 60,000, which were present in all SV40-transformed cell lines examined so far, including those obtained by chromosome-mediated gene transfer. The 55K proteins were not structurally related to large-T antigens, as judged by the Chromobead elution patterns of their methionine-labeled tryptic peptides. Our data are compatible with the assumption that the 55K proteins are largely or totally cell coded.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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