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. Author manuscript; available in PMC: 2013 Jan 3.
Published in final edited form as: Biomacromolecules. 2007 Dec 8;9(1):142–148. doi: 10.1021/bm700918d

Figure 8.

Figure 8

Biocompatibility and slow release property of IPN hydrogel were assessed in vivo. Balb/c mice were subcutaneously implanted with either fluorescein or fluorescein loaded IPN gel. At 24 hours post implantation, the animals were sacrificed and the implant-surrounding tissues were recovered for histological analyses. H&E stain shows that (A) fluorescein injection triggers minimal tissue response whereas (B) hydrogel implant prompt mild inflammatory responses. On the other hand, fluorescence images of the tissues reveal that (C) a small amount of residual fluorescein was present in the fluorescein-injected tissue though (D) large amount of fluorescein still reside in the IPN hydrogel implanted tissue.