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. 1980 Nov;36(2):627–631. doi: 10.1128/jvi.36.2.627-631.1980

Viruses isolated from cells persistently infected with vesicular stomatitis virus show altered interactions with defective interfering particles.

F M Horodyski, J J Holland
PMCID: PMC353685  PMID: 6253684

Abstract

Virus mutants isolated from persistent infections of vesicular stomatitis virus in BHK-21 cells were much less susceptible to interference mediated by the defective interfering particle used to establish the persistent infection. This mutational change occurred as early as 34 days in the persistent infection and continued for over 5 years. The earliest variants showed no oligonucleotide map changes and no difference in the temperature-sensitive phenotype from the original virus, but the later variants exhibited extensive map changes. These results suggest a possible role for defective interfering particles in the selection of the mutants.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmed R., Graham A. F. Persistent infections in L cells with temperature-sensitive mutants of reovirus. J Virol. 1977 Aug;23(2):250–262. doi: 10.1128/jvi.23.2.250-262.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BELLETT A. J., COOPER P. D. Some properties of the transmissible interfering component of vesicular stomatitis virus preparations. J Gen Microbiol. 1959 Dec;21:498–509. doi: 10.1099/00221287-21-3-498. [DOI] [PubMed] [Google Scholar]
  3. Doyle M., Holland J. J. Prophylaxis and immunization in mice by use of virus-free defective T particles to protect against intracerebral infection by vesicular stomatitis virus. Proc Natl Acad Sci U S A. 1973 Jul;70(7):2105–2108. doi: 10.1073/pnas.70.7.2105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Holland J. J., Grabau E. A., Jones C. L., Semler B. L. Evolution of multiple genome mutations during long-term persistent infection by vesicular stomatitis virus. Cell. 1979 Mar;16(3):495–504. doi: 10.1016/0092-8674(79)90024-2. [DOI] [PubMed] [Google Scholar]
  5. Holland J. J., Villarreal L. P. Persistent noncytocidal vesicular stomatitis virus infections mediated by defective T particles that suppress virion transcriptase. Proc Natl Acad Sci U S A. 1974 Aug;71(8):2956–2960. doi: 10.1073/pnas.71.8.2956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Holland J. J., Villarreal L. P., Welsh R. M., Oldstone M. B., Kohne D., Lazzarini R., Scolnick E. Long-term persistent vesicular stomatitis virus and rabies virus infection of cells in vitro. J Gen Virol. 1976 Nov;33(2):193–211. doi: 10.1099/0022-1317-33-2-193. [DOI] [PubMed] [Google Scholar]
  7. Huang A. S., Baltimore D. Defective viral particles and viral disease processes. Nature. 1970 Apr 25;226(5243):325–327. doi: 10.1038/226325a0. [DOI] [PubMed] [Google Scholar]
  8. Kawai A., Matsumoto S. Interfering and noninterfering defective particles generated by a rabies small plaque variant virus. Virology. 1977 Jan;76(1):60–71. doi: 10.1016/0042-6822(77)90282-3. [DOI] [PubMed] [Google Scholar]
  9. Kawai A., Matsumoto S., Tanabe K. Characterization of rabies viruses recovered from persistently infected BHK cells. Virology. 1975 Oct;67(2):520–533. doi: 10.1016/0042-6822(75)90452-3. [DOI] [PubMed] [Google Scholar]
  10. Leppert M., Kort L., Kolakofsky D. Further characterization of Sendai virus DI-RNAs: a model for their generation. Cell. 1977 Oct;12(2):539–552. doi: 10.1016/0092-8674(77)90130-1. [DOI] [PubMed] [Google Scholar]
  11. Meinkoth J., Kennedy S. I. Semliki forest virus persistence in mouse L929 cells. Virology. 1980 Jan 15;100(1):141–155. doi: 10.1016/0042-6822(80)90560-7. [DOI] [PubMed] [Google Scholar]
  12. Mudd J. A., Leavitt R. W., Kingsbury D. T., Holland J. J. Natural selection of mutants of vesicular stomatitis virus by cultured cells of Drosophila melanogaster. J Gen Virol. 1973 Sep;20(3):341–351. doi: 10.1099/0022-1317-20-3-341. [DOI] [PubMed] [Google Scholar]
  13. Nishiyama Y., Ito Y., Shimokata K. Properties of the viruses selected during persistent infection of L cells with VSV. J Gen Virol. 1978 Aug;40(2):481–484. doi: 10.1099/0022-1317-40-2-481. [DOI] [PubMed] [Google Scholar]
  14. Nishiyama Y. Studies of L cells persistently infected with VSV: factors involved in the regulation of persistent infection. J Gen Virol. 1977 May;35(2):265–279. doi: 10.1099/0022-1317-35-2-265. [DOI] [PubMed] [Google Scholar]
  15. Popescu M., Lehmann-Grube F. Defective interfering particles in mice infected with lymphocytic choriomeningitis virus. Virology. 1977 Mar;77(1):78–83. doi: 10.1016/0042-6822(77)90407-x. [DOI] [PubMed] [Google Scholar]
  16. Preble O. T., Youngner J. S. Temperature-sensitive defect of mutants isolated from L cells persistently infected with Newcastle disease virus. J Virol. 1973 Sep;12(3):472–480. doi: 10.1128/jvi.12.3.472-480.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Rima B. K., Davidson W. B., Martin S. J. The role of defective interfering particles in persistent infection of Vero cells by measles virus. J Gen Virol. 1977 Apr;35(1):89–97. doi: 10.1099/0022-1317-35-1-89. [DOI] [PubMed] [Google Scholar]
  18. Rowlands K., Grabau E., Spindler K., Jones C., Semler B., Holland J. Virus protein changes and RNA termini alterations evolving during persistent infection. Cell. 1980 Apr;19(4):871–880. doi: 10.1016/0092-8674(80)90078-1. [DOI] [PubMed] [Google Scholar]
  19. Schmaljohn C., Blair C. D. Persistent infection of cultured mammalian cells by Japanese encephalitis virus. J Virol. 1977 Nov;24(2):580–589. doi: 10.1128/jvi.24.2.580-589.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Semler B. L., Holland J. J. Persistent vesicular stomatitis virus infection mediates base substitutions in viral RNA termini. J Virol. 1979 Nov;32(2):420–428. doi: 10.1128/jvi.32.2.420-428.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. WAGNER R. R., LEVEY A. H., SNYDER R. M., RATCLIFF G. A., Jr, HYATT D. F. BIOLOGIC PROPERTIES OF TWO PLAQUE VARIANTS OF VESICULAR STOMATITIS VIRUS (INDIANA SEROTYPE). J Immunol. 1963 Jul;91:112–122. [PubMed] [Google Scholar]
  22. Weiss B., Rosenthal R., Schlesinger S. Establishment and maintenance of persistent infection by Sindbis virus in BHK cells. J Virol. 1980 Jan;33(1):463–474. doi: 10.1128/jvi.33.1.463-474.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Welsh R. M., Burner P. A., Holland J. J., Oldstone M. B., Thompson H. A., Villarreal L. P. A comparison of biochemical and biological properties of standard and defective lymphocytic choriomeningitis virus. Bull World Health Organ. 1975;52(4-6):403–408. [PMC free article] [PubMed] [Google Scholar]
  24. Youngner J. S., Dubovi E. J., Quagliana D. O., Kelly M., Preble O. T. Role of temperature-sensitive mutants in persistent infections initiated with vesicular stomatitis virus. J Virol. 1976 Jul;19(1):90–101. doi: 10.1128/jvi.19.1.90-101.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]

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