Fig. 1.

(a) Weight gain (% of baseline) over 12 weeks in animals grafted with human islets from four donors. White squares, HFD grafts (n = 23); black squares, controls (n = 22) (linear mixed model, see Methods, ***p < 0.001). (b) Serum triacylglycerol levels at 12 weeks (*p < 0.05 vs controls). (c) MRI was used to quantify (10 sections/mouse) abdominal fat content (expressed as a percentage ± SEM) before the mice were killed (HFD 52.27 ± 4.39% vs controls 25.7 ± 0.604%, *p < 0.05, fat appears in white)