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. 1977 Jan;21(1):16–23. doi: 10.1128/jvi.21.1.16-23.1977

Photodynamic treatment of herpes simplex virus during its replicative cycle.

N C Khan, J L Melnick, N Biswal
PMCID: PMC353786  PMID: 189063

Abstract

Photodynamic treatment of herpes simplex virus type 1-infected hamster embryo fibroblasts (LSH strain) with a low concentration of proflavine (0.08 mug/10(5) cells per ml), a 3-9-diamine acridine dye, inhibited production not only of infectious progeny but also of virion particles. However, there was no appreciable inhibition of viral or cellular DNA synthesis, even when the infected cells were repeatedly exposed to this low concentration of dye and light during the replication cycle of the virus. It thus appears that photodynamic treatment of infected cells interferes with the processes involved in virus maturation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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