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. 1977 Jan;21(1):309–318. doi: 10.1128/jvi.21.1.309-318.1977

Six-NB-tropic murine leukemia viruses derived from a B-tropic virus of BALB/c have altered p30.

N Hopkins, J Schindler, R Hynes
PMCID: PMC353817  PMID: 189069

Abstract

We have examined the electrophoretic mobility on sodium dodecyl sulfate-polyacrylamide gels of three virion proteins of B-tropic murine leukemia virus from BALB/c and six of its NB-tropic derivatives. The gp70 protein and a 13,000-molecular-weight virion protein tentatively identified as p15 of the NB-tropic viruses migrated with the corresponding B virus proteins. However, the major internal structural protein of type C virions, p30, of all the NB-tropic viruses migrated more rapidly than the p30 of their B virus progenitor. Although this change in p30 raises the possibility that p30 may be involved in determining the N-, B-, or NB-tropism of MuLV's, it is also possible that the change accompanies but does not directly determine the change in tropsim.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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