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. 1978 Jan;25(1):42–50. doi: 10.1128/jvi.25.1.42-50.1978

Inhibition of herpes simplex virus type 1 replication in temperature-sensitive cell cycle mutants.

K Yanagi, A Talavera, T Nishimoto, M G Rush
PMCID: PMC353899  PMID: 202752

Abstract

Herpes simplex virus type 1 DNA synthesis and infections progeny production were studied in five different conditional hamster (BHK-21) cell cycle mutants. At the nonpermissive temperature (39.5 degrees C), both events were strongly inhibited in four of these cell lines. The degree of inhibition was a reproducible characteristic of each cell mutant and in two cases was dependent upon the multiplicity of infection. Experiments involving shifts to the nonpermissive temperature at least 3 h postinfection at 33.5 degrees C suggested that the defects in viral replication were not due to faulty adsorption, penetration, or uncoating, whereas experiments involving shifts of infected cells from the nonpermissive temperature to 33.5 degrees C revealed the reversible nature of the inhibition.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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