Table 2.
Frequency Distributions of BRAF Single-Nucleotide Polymorphisms' Genotypes in Cases and Controls and the Associations with Papillary Thyroid Cancer Risk Stratified by Alcohol Drinking Status
| |
No |
Yes |
||||
|---|---|---|---|---|---|---|
| Variants | Cases, n (%) | Controls, n (%) | OR [CI]a | Cases, n (%) | Controls, n (%) | OR [CI]a |
| rs1042179: A>G | ||||||
| AA | 248 (70.7) | 314 (71.9) | 1.00 | 11 (68.8) | 87 (69.6) | 1.00 |
| AG | 94 (26.8) | 110 (25.2) | 1.09 [0.78–1.51] | 4 (25.0) | 36 (28.8) | 0.91 [0.26–3.12] |
| GG | 9 (2.6) | 13 (3.0) | 0.89 [0.37–2.16] | 1 (6.3) | 2 (1.6) | 3.09 [0.24–39.16] |
| GG+AG | 103 (29.3) | 123 (28.1) | 1.07 [0.78–1.47] | 5 (31.3) | 38 (30.4) | 1.06 [0.34–3.34] |
| rs11762469: A>T | ||||||
| AA | 235 (66.8) | 303 (69.3) | 1.00 | 13 (81.3) | 88 (69.8) | 1.00 |
| AT | 108 (30.7) | 124 (28.4) | 1.12 [0.81–1.53] | 3 (18.8) | 34 (27.0) | 0.62 [0.16–2.38] |
| TT | 9 (2.6) | 10 (2.3) | 1.25 [0.49–3.16] | 0 (0.0) | 4 (3.2) | — |
| AT+TT | 117 (33.2) | 134 (30.7) | 1.13 [0.83–1.53] | 3 (18.8) | 38 (30.2) | 0.53 [0.14–2.01] |
| rs17161747: G>C | ||||||
| GG | 236 (67.0) | 281 (64.6) | 1.00 | 8 (50.0) | 92 (73.0) | 1.00 |
| GC | 103 (29.3) | 134 (30.8) | 0.88 [0.64–1.21] | 8 (50.0) | 31 (24.6) | 2.77 [0.94.8.15] |
| CC | 13 (3.7) | 20 (4.6) | 0.83 [0.40–1.72] | 0 (0.0) | 3 (2.4) | — |
| GC+CC | 116 (33.0) | 154 (35.4) | 0.88 [0.65–1.19] | 8 (50.0) | 34 (27.0) | 2.50 [0.85–7.31] |
| rs3748093: T>A | ||||||
| TT | 210 (59.8) | 274 (64.6) | 1.00 | 9 (56.3) | 68 (54.0) | 1.00 |
| AT | 122 (34.8) | 137 (32.3) | 1.16 [0.85–1.58] | 6 (37.5) | 46 (36.5) | 0.97 [0.32–2.98] |
| AA | 19 (5.4) | 13 (3.1) | 2.12 [1.00–4.47]b | 1 (6.3) | 12 (9.5) | 0.67 [0.08–5.99] |
| AT+AA | 141 (40.2) | 150 (35.4) | 1.24 [0.92–1.67] | 7 (43.8) | 58 (46.0) | 0.91 [0.31–2.67] |
a
ORs are adjusted for age, sex, cancer familial history, and smoking.
b
Boldface indicates statistical significance (p<0.05).