Abstract
The biochemical transformation of thymidine kinase-deficient cells by UV-inactivated herpes simplex virus is enhanced by low-level photodynamic treatment of the infected cells. At the concentration of proflavine used, the virus was not inactivated and both virus and cellular DNA syntheses were only marginally inhibited. The observed enhancement of the transfer of a virus gene to the cell genome suggests a possible cocarcinogenic role for photodynamically active dyes at very low concentrations.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Altman S., Lerman L. S. Effects of 9-aminoacridine on bacteriophage T4 deoxyribonucleic acid synthesis. J Mol Biol. 1970 Jun 14;50(2):263–277. doi: 10.1016/0022-2836(70)90191-9. [DOI] [PubMed] [Google Scholar]
- Khan N. C., Melnick J. L., Biswal N. Photodynamic treatment of herpes simplex virus during its replicative cycle. J Virol. 1977 Jan;21(1):16–23. doi: 10.1128/jvi.21.1.16-23.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Li J. L., Jerkofsky M. A., Rapp F. Demonstration of oncogenic potential of mammalian cells transformed by DNA-containing viruses following photodynamic inactivation. Int J Cancer. 1975 Feb 15;15(2):190–202. doi: 10.1002/ijc.2910150204. [DOI] [PubMed] [Google Scholar]
- Rapp F., Li J. L., Jerkofsky M. Transformation of mammalian cells by DNA-containing viruses following photodynamic inactivation. Virology. 1973 Oct;55(2):339–346. doi: 10.1016/0042-6822(73)90173-6. [DOI] [PubMed] [Google Scholar]