Figure 8.

Analysis of incidence and histopathology of pulmonary tumors from induced transgenic mice. (A) Lung sections from tumor-bearing mice were either H&E stained or immunostained for Ki67 (brown). Arrows indicate tumor foci. (B) Immunohistochemistry of tumor-bearing lung sections for lung differentiation markers as indicated. Arrows show rare Scgb1a1-positive tumor cells that were never detected in spontaneous lung tumor but in their surrounding bronchioles. (C and D) Staining of lung tumor sections with the indicated markers. Arrows in C show Alcian Blue.positive vessel and those in D show vimentin-positive vessel. Two representative pictures were shown for each staining.