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. 1978 Aug;27(2):347–356. doi: 10.1128/jvi.27.2.347-356.1978

Defective interfering particles of parvovirus H-1.

S L Rhode 3rd
PMCID: PMC354173  PMID: 691114

Abstract

Defective interfering particles of the parvovirus H-1 were produced by serial propagation at high multiplicities of infection. Such particles interfere with the synthesis of capsid proteins and infectious virus of standard H-1. The interference is sensitive to UV irradiation, dependent on the multiplicity of the challenge virus, and is active in heterotypic infections against parvovirus H-3 or LuIII. Defective interfering particle genomes have alterations characterized by integral numbers (1 to 10 or more) of a 60-base-pair addition in the neighborhood of the origin of replicative-form DNA replication and deletions that are located primarily within two regions, 32 to 44 or 80 to 90 on the genome map. Some of the implications of these findings are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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