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. 1978 Aug;27(2):443–448. doi: 10.1128/jvi.27.2.443-448.1978

Proteolysis of noncapsid protein 2 of type 3 poliovirus at the restrictive temperature: breakdown of noncapsid protein 2 correlates with loss of RNA synthesis.

S A Bowles, D R Tershak
PMCID: PMC354183  PMID: 211270

Abstract

Inhibition of RNA synthesis of the LH strain of type 3 poliovirus at the restrictive temperature occurs concurrently with the breakdown of noncapsid virus-specific peptide 2. This finding, along with other reported data (B.D. Korant, In Proteases and Biological Control, p. 621-644, 1975), suggests that noncapsid virus-specific peptide 2 is a component of the viral replicase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adler R., Tershak D. R. Temperature-sensitive defect of type 2 poliovirus. Virology. 1974 Mar;58(1):209–218. doi: 10.1016/0042-6822(74)90155-x. [DOI] [PubMed] [Google Scholar]
  2. Butterworth B. E., Shimshick E. J., Yin F. H. Association of the polioviral RNA polymerase complex with phospholipid membranes. J Virol. 1976 Aug;19(2):457–466. doi: 10.1128/jvi.19.2.457-466.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Caliguiri L. A., Mosser A. G. Proteins associated with the poliovirus RNA replication complex. Virology. 1971 Nov;46(2):375–386. doi: 10.1016/0042-6822(71)90039-0. [DOI] [PubMed] [Google Scholar]
  4. Cooper P. D., Geissler E., Scotti P. D., Tannock G. A. Further characterization of the genetic map of poliovirus temperature-sensitive mutants. In: strategy of the viral genome. Ciba Found Symp. 1971:75–100. doi: 10.1002/9780470719824.ch5. [DOI] [PubMed] [Google Scholar]
  5. Lundquist R. E., Ehrenfeld E., Maizel J. V., Jr Isolation of a viral polypeptide associated with poliovirus RNA polymerase. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4773–4777. doi: 10.1073/pnas.71.12.4773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Röder A., Koschel K. Virus-specific proteins associated with the replication complex of poliovirus RNA. J Gen Virol. 1975 Jul;28(1):85–98. doi: 10.1099/0022-1317-28-1-85. [DOI] [PubMed] [Google Scholar]
  7. Saborio J. L., Pong S. S., Koch G. Selective and reversible inhibition of initiation of protein synthesis in mammalian cells. J Mol Biol. 1974 May 15;85(2):195–211. doi: 10.1016/0022-2836(74)90360-x. [DOI] [PubMed] [Google Scholar]
  8. Summers D. F., Maizel J. V., Jr Determination of the gene sequence of poliovirus with pactamycin. Proc Natl Acad Sci U S A. 1971 Nov;68(11):2852–2856. doi: 10.1073/pnas.68.11.2852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Taber R., Rekosh D., Baltimore D. Effect of pactamycin on synthesis of poliovirus proteins: a method for genetic mapping. J Virol. 1971 Oct;8(4):395–401. doi: 10.1128/jvi.8.4.395-401.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Tershak D. R. Effect of hypertonic medium on protein synthesis of Mahoney and LSc poliovirus. J Virol. 1976 Dec;20(3):597–603. doi: 10.1128/jvi.20.3.597-603.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Wright P. J., Cooper P. D. Poliovirus proteins associated with the replication complex in infected cells. J Gen Virol. 1976 Jan;30(1):63–71. doi: 10.1099/0022-1317-30-1-63. [DOI] [PubMed] [Google Scholar]

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