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. 1975 Feb;15(2):423–427. doi: 10.1128/jvi.15.2.423-427.1975

RNA subunit structure of Mason-Pfizer monkey virus.

G Schochetman, J Schlom
PMCID: PMC354470  PMID: 803570

Abstract

Mason-Pfizer monkey virus 60-70S RNA has a molecular weight of 8 times 10-6 when analyzed on polyacrylamide gels. Dissociation of 60-70S RNA of Mason-Pfizer monkey virus and murine leukemia virus by heat or formamide (40%) resulted in conversion to identical subunit structures of 2.8 times 10-6 daltons; treatment with lower amounts of formamide revealed a partial dissociation of Mason-Pfizer monkey virus 60-70S RNA released three low-molecular-weight RNA species of 10-5, 3,5 times 10-4, and 2.5 times 10-4.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abrell J. W., Gallo R. C. Purification, characterization, and comparison of the DNA polymerases from two primate RNA tumor viruses. J Virol. 1973 Sep;12(3):431–439. doi: 10.1128/jvi.12.3.431-439.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bader J. P., Steck T. L. Analysis of the ribonucleic acid of murine leukemia virus. J Virol. 1969 Oct;4(4):454–459. doi: 10.1128/jvi.4.4.454-459.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bishop D. H., Claybrook J. R., Spiegelman S. Electrophoretic separation of viral nucleic acids on polyacrylamide gels. J Mol Biol. 1967 Jun 28;26(3):373–387. doi: 10.1016/0022-2836(67)90310-5. [DOI] [PubMed] [Google Scholar]
  4. Blair C. D., Duesberg P. H. Structure of Rauscher mouse leukaemia virus RNA. Nature. 1968 Oct 26;220(5165):396–399. doi: 10.1038/220396a0. [DOI] [PubMed] [Google Scholar]
  5. Canaani E., Duesberg P. Role of subunits of 60 to 70S avian tumor virus ribonucleic acid in its template activity for the viral deoxyribonucleic acid polymerase. J Virol. 1972 Jul;10(1):23–31. doi: 10.1128/jvi.10.1.23-31.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cheung K. S., Smith R. E., Stone M. P., Joklik W. K. Comparison of immature (rapid harvest) and mature Rous sarcoma virus particles. Virology. 1972 Dec;50(3):851–864. doi: 10.1016/0042-6822(72)90439-4. [DOI] [PubMed] [Google Scholar]
  7. Chopra H. C., Mason M. M. A new virus in a spontaneous mammary tumor of a rhesus monkey. Cancer Res. 1970 Aug;30(8):2081–2086. [PubMed] [Google Scholar]
  8. Duesberg P. H. On the structure of RNA tumor viruses. Curr Top Microbiol Immunol. 1970;51:78–104. [PubMed] [Google Scholar]
  9. Duesberg P. H. Physical properties of Rous Sarcoma Virus RNA. Proc Natl Acad Sci U S A. 1968 Aug;60(4):1511–1518. doi: 10.1073/pnas.60.4.1511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Erikson E., Erikson R. L. Association of 4S ribonucleic acid with oncornavirus ribonucleic acids. J Virol. 1971 Aug;8(2):254–256. doi: 10.1128/jvi.8.2.254-256.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Erikson R. L. Studies on the RNA from avian myeloblastosis virus. Virology. 1969 Jan;37(1):124–131. doi: 10.1016/0042-6822(69)90313-4. [DOI] [PubMed] [Google Scholar]
  12. Faras A. J., Garapin A. C., Levinson W. E., Bishop J. M., Goodman H. M. Characterization of the low-molecular-weight RNAs associated with the 70S RNA of Rous sarcoma virus. J Virol. 1973 Aug;12(2):334–342. doi: 10.1128/jvi.12.2.334-342.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hill M., Hillova J. RNA and DNA forms of the genetic material of C-type viruses and the integrated state of the DNA form in the cellular chromosome. Biochim Biophys Acta. 1974 Apr 29;355(1):7–48. doi: 10.1016/0304-419x(74)90006-7. [DOI] [PubMed] [Google Scholar]
  14. Manning J. S., Hackett A. J. Morphological and biophysical properties of the Mason-Pfizer monkey virus. J Natl Cancer Inst. 1972 Feb;48(2):417–422. [PubMed] [Google Scholar]
  15. Mason M. M., Bogden A. E., Ilievski V., Esber H. J., Baker J. R., Chopra H. C. History of a rhesus monkey adenocarcinoma containing virus particles resembling oncogenic RNA viruses. J Natl Cancer Inst. 1972 May;48(5):1323–1331. [PubMed] [Google Scholar]
  16. Nowinski R. C., Edynak E., Sarkar N. H. Serological and structural properties of Mason-Pfizer monkey virus isolated from the mammary tumor of a Rhesus monkey. Proc Natl Acad Sci U S A. 1971 Jul;68(7):1608–1612. doi: 10.1073/pnas.68.7.1608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Schlom J., Colcher D., Spiegelman S., Gillespie S., Gillespie D. Quantitation of RNA tumor viruses and viruslike particles in human milk by hybridization to polyadenylic acid sequences. Science. 1973 Feb 16;179(4074):696–698. doi: 10.1126/science.179.4074.696. [DOI] [PubMed] [Google Scholar]
  18. Schlom J., Spiegelman S. DNA polymerase activities and nucleic acid components of virions isolated from a spontaneous mammary carcinoma from a rhesus monkey. Proc Natl Acad Sci U S A. 1971 Jul;68(7):1613–1617. doi: 10.1073/pnas.68.7.1613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Schlom J., Spiegelman S. Simultaneous detection of reverse transcriptase and high molecular weight RNA unique to oncogenic RNA viruses. Science. 1971 Nov 19;174(4011):840–843. doi: 10.1126/science.174.4011.840. [DOI] [PubMed] [Google Scholar]
  20. Trávnícek M., Ríman J. Subunits of oncornavirus high-molecular-weight RNA. I. Stepwise conversion of 60 S AMV (avian myeloblastosis virus) RNA to subunits. Biochem Biophys Res Commun. 1973 Jul 2;53(1):217–223. doi: 10.1016/0006-291x(73)91422-8. [DOI] [PubMed] [Google Scholar]
  21. Yaniv A., Ono T., Kacian D., Colcher D., Witkin S., Schlom J., Spiegelman S. Serological analysis of reverse transcriptase of the Mason-Pfizer monkey virus. Virology. 1974 May;59(1):335–338. doi: 10.1016/0042-6822(74)90233-5. [DOI] [PubMed] [Google Scholar]

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