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. 1975 Feb;15(2):433–437. doi: 10.1128/jvi.15.2.433-437.1975

Posttranscriptional Selection of Simian Virus 40-Specific RNA

George Khoury *, Peter Howley †, Daniel Nathans †, Malcolm Martin †
PMCID: PMC354473  PMID: 163366

Abstract

Analysis of the viral-specific RNA in simian virus 40(SV40)-infected monkey kidney cells indicated the extensive transcription of both DNA strands. These symmetrically transcribed sequences were localized in the nucleus of infected cells, whereas only the “true” early and late SV40 transcripts were found in the cytoplasm. These results suggest that selective posttranscriptional degradation and/or transport occurs after transcription of the viral DNA. On the basis of hybridization experiments with cytoplasmic RNA and the separated strands of the SV40 Hin fragments, the early SV40 region appears to include all of Hin fragments A, H, I, and B (48% of the genome), whereas the late region is represented in Hin fragments C, D, E, K, F, J, and G (52% of the genome).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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