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. 1975 May;15(5):1281–1283. doi: 10.1128/jvi.15.5.1281-1283.1975

Inhibition of DNA Polymerase from Herpes Simplex Virus-Infected Wi-38 Cells by Phosphonoacetic Acid

J C-H Mao 1, Ellen E Robishaw 1, L R Overby 1
PMCID: PMC354586  PMID: 16789161

Abstract

Infection of Wi-38 cells with herpes simplex virus induced an elevated DNA polymerase activity which had many biochemical properties different from normal cell DNA polymerase. Phosphonoacetic acid specifically inhibited the virus-induced DNA polymerase as compared to the normal WI-38 cell DNA polymerase. The compound did not appear to inhibit enzyme activity by interacting with the DNA primer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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