Skip to main content
Journal of Virology logoLink to Journal of Virology
. 1975 Jun;15(6):1511–1513. doi: 10.1128/jvi.15.6.1511-1513.1975

Effect of DNA-negative and maturation-defective conditions on accumulation of functional messengers for T4 bacteriophage-specific dihydrofolate reductase and deoxynucleoside monophosphate kinase.

H Witmer
PMCID: PMC354620  PMID: 167197

Abstract

Messengers for T4 phage-specific deoxynucleoside monophosphate kinase overaccumulated in nonpermissive hosts infected with amber-defective viruses that displayed either the DNA-negative or maturation-defective phenotype. Under both conditions, however, transcription of functional messengers for dihydrofolate reductase followed essentially normal kinetics.

Full text

PDF
1511

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bolle A., Epstein R. H., Salser W., Geiduschek E. P. Transcription during bacteriophage T4 development: requirements for late messenger synthesis. J Mol Biol. 1968 Apr 28;33(2):339–362. doi: 10.1016/0022-2836(68)90193-9. [DOI] [PubMed] [Google Scholar]
  2. Guha A., Szybalski W., Salser W., Geiduschek E. P., Pulitzer J. F., Bolle A. Controls and polarity of transcription during bacteriophage T4 development. J Mol Biol. 1971 Jul 28;59(2):329–349. doi: 10.1016/0022-2836(71)90054-4. [DOI] [PubMed] [Google Scholar]
  3. Johnson J. R., Hall D. H. Characterization of new regulatory mutants of bacteriophage T4. J Virol. 1974 Mar;13(3):666–676. doi: 10.1128/jvi.13.3.666-676.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kennell D., Simmons C. Synthesis and decay of messenger ribonucleic acid from the lactose operon of Escherichia coli during amino-acid starvation. J Mol Biol. 1972 Oct 14;70(3):451–464. doi: 10.1016/0022-2836(72)90552-9. [DOI] [PubMed] [Google Scholar]
  5. Matthews C. K. Deoxyribonucleic acid metabolism and virus-induced enzyme synthesis in a thymine-requiring bacterium infected by a thymine-requiring bacteriophage. Biochemistry. 1966 Jun;5(6):2092–2100. doi: 10.1021/bi00870a042. [DOI] [PubMed] [Google Scholar]
  6. Sakiyama S., Buchanan J. M. Control of the synthesis of T4 phage deoxynucleotide kinase messenger ribonucleic acid in vivo. J Biol Chem. 1972 Dec 10;247(23):7806–7814. [PubMed] [Google Scholar]
  7. Sippel A., Hartmann G. Mode of action of rafamycin on the RNA polymerase reaction. Biochim Biophys Acta. 1968 Mar 18;157(1):218–219. doi: 10.1016/0005-2787(68)90286-4. [DOI] [PubMed] [Google Scholar]
  8. Trimble R. B., Galivan J., Maley F. The temporal expression of T2r + bacteriophage genes in vivo and in vitro. Proc Natl Acad Sci U S A. 1972 Jul;69(7):1659–1663. doi: 10.1073/pnas.69.7.1659. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Warner H. R., Lewis N. The synthesis of deoxycytidylate deaminase and dihydrofolate reductase and its control in Escherichia coli infected with bacteriophage T4 and T-4 amber mutants. Virology. 1966 May;29(1):172–175. doi: 10.1016/0042-6822(66)90208-x. [DOI] [PubMed] [Google Scholar]
  10. Wehrli W., Knüsel F., Staehelin M. Action of rifamycin on RNA-polymerase from sensitive and resistant bacteria. Biochem Biophys Res Commun. 1968 Jul 26;32(2):284–288. doi: 10.1016/0006-291x(68)90382-3. [DOI] [PubMed] [Google Scholar]
  11. Wehrli W., Nüesch J., Knüsel F., Staehelin M. Action of rifamycins on RNA polymerase. Biochim Biophys Acta. 1968 Mar 18;157(1):215–217. doi: 10.1016/0005-2787(68)90285-2. [DOI] [PubMed] [Google Scholar]
  12. Wilhelm J. M., Haselkorn R. In vitro synthesis of T4 proteins: the products of genes 9, 18, 19, 23, 24, and 38. Virology. 1971 Jan;43(1):198–208. doi: 10.1016/0042-6822(71)90237-6. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES