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. 1975 Jul;16(1):27–33. doi: 10.1128/jvi.16.1.27-33.1975

Analysis of antigenic determinants of structural polypeptides of avian type C tumor viruses.

J R Stephenson, E J Smith, L B Crittenden, S A Aaronson
PMCID: PMC354628  PMID: 48560

Abstract

Radioimmunoassays were developed for the 19,000, 15,000, and 12,000 molecular weight polypeptides of avian myeloblastosis virus and for the 19,000 and 12,000 polypeptides of RAV-0, a subgroup E avian tumor virus. Each polypeptide was shown to possess both group- and type-specific antigenic determinants, in contrast to the 27,000 mol wt polypeptide, which contained only group-specific determinants. The corresponding low-molecular-weight polypeptides of subgroup A, B, and E viruses were shown to be immunologically indistinguishable. The findings that low-molecular-weight polypeptides of subgroup C and D viruses reacted very differently in immunoassays for the respective polypeptides of avian myeloblastosis virus or RAV-0 suggest that subgroups C and D may have evolved differently form subgroups A, B, and E.

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Selected References

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