Abstract
The synthesis of vaccinia virus-induced thymidine kinase is normally arrested several hours after infection. In thymidine kinase-deficient LM cells infected with IHD strain of vaccinia virus, arrest occurs whether or not viral DNA synthesis is inhibited. With virus inactivated by UV irradiation, enzyme synthesis takes place, but arrest is abolished. It is suggested that an early viral genetic function is responsible for the cessation of thymidine kinase synthesis.
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- JOKLIK W. K. The purification fo four strains of poxvirus. Virology. 1962 Sep;18:9–18. doi: 10.1016/0042-6822(62)90172-1. [DOI] [PubMed] [Google Scholar]
- Jungwirth C., Joklik W. K. Studies on "early" enzymes in HeLa cells infected with vaccinia virus. Virology. 1965 Sep;27(1):80–93. doi: 10.1016/0042-6822(65)90145-5. [DOI] [PubMed] [Google Scholar]
- KIT S., DUBBS D. R., PIEKARSKI L. J., HSU T. C. DELETION OF THYMIDINE KINASE ACTIVITY FROM L CELLS RESISTANT TO BROMODEOXYURIDINE. Exp Cell Res. 1963 Aug;31:297–312. doi: 10.1016/0014-4827(63)90007-7. [DOI] [PubMed] [Google Scholar]
- KIT S., PIEKARSKI L. J., DUBBS D. R. EFFECTS OF 5-FLUOROURACIL, ACTINOMYCIN D AND MITOMYCIN C ON THE INDUCTION OF THYMIDINE KINASE BY VACCINIA-INFECTED L-CELLS. J Mol Biol. 1963 Nov;7:497–510. doi: 10.1016/s0022-2836(63)80097-2. [DOI] [PubMed] [Google Scholar]
- KIT S., PIEKARSKI L. J., DUBBS D. R. Induction of thymidine kinase by vaccinia-infected mouse fibroblasts. J Mol Biol. 1963 Jan;6:22–33. doi: 10.1016/s0022-2836(63)80078-9. [DOI] [PubMed] [Google Scholar]
- Kates J. R., McAuslan B. R. Messenger RNA synthesis by a "coated" viral genome. Proc Natl Acad Sci U S A. 1967 Feb;57(2):314–320. doi: 10.1073/pnas.57.2.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kit S. Viral-induced enzymes and the problem of viral oncogenesis. Adv Cancer Res. 1968;11:73–221. doi: 10.1016/s0065-230x(08)60388-7. [DOI] [PubMed] [Google Scholar]
- MCAUSLAN B. R. THE INDUCTION AND REPRESSION OF THYMIDINE KINASE IN THE POXVIRUS-INFECTED HELA CELL. Virology. 1963 Nov;21:383–389. doi: 10.1016/0042-6822(63)90199-5. [DOI] [PubMed] [Google Scholar]
- MUNYON W., KIT S. INHIBITION OF THYMIDINE KINASE FORMATION IN LM (TK-) CELLS SIMULTANEOUSLY INFECTED WITH VACCINIA AND A THYMIDINE KINASELESS VACCINIA MUTANT. Virology. 1965 Jun;26:374–377. doi: 10.1016/0042-6822(65)90287-4. [DOI] [PubMed] [Google Scholar]
- Munyon W. H., Kit S. Induction of cytoplasmic ribonucleic acid (RNA) synthesis in vaccinia-infected LM cells during inhibition of protein synthesis. Virology. 1966 Jun;29(2):303–309. doi: 10.1016/0042-6822(66)90037-7. [DOI] [PubMed] [Google Scholar]
- Munyon W., Buchsbaum R., Paoletti E., Mann J., Kraiselburd E., Davis D. Electrophoresis of thymidine kinase activity synthesized by cells transformed by herpes simplex virus. Virology. 1972 Sep;49(3):683–689. doi: 10.1016/0042-6822(72)90525-9. [DOI] [PubMed] [Google Scholar]
- Woodson B. Vaccinia mRNA synthesis under conditions which prevent uncoating. Biochem Biophys Res Commun. 1967 Apr 20;27(2):169–175. doi: 10.1016/s0006-291x(67)80057-3. [DOI] [PubMed] [Google Scholar]