Table 4.

Unadjusted and adjusted odds of developing future ischemic stroke according to quartile of lipid biomarkers at baseline

Variable (Quartile cut-points)	Odds Ratio (95% Confidence interval)
	1	2	3	4	P for trend
Total cholesterol (205.0, 230.0, 254.5)
Unadjusted (case/control pairs=727)	1.0	1.25 (0.93, 1.69)	1.14 (0.85, 1.53)	1.19 (0.89, 1.61)	0.38
Adjusted (case/control pairs=727)	1.0	1.15 (0.84, 1.58)	1.06 (0.77, 1.45)	1.08 (0.78, 1.50)	0.80
Total cholesterol/HDL (3.1, 3.9, 5.0)
Unadjusted (case/control pairs=726)	1.0	1.26 (0.92, 1.71)	1.39 (1.04, 1.87)	1.54 (1.14, 2.10)	<0.01
Adjusted (case/control pairs=726)	1.0	1.21 (0.87, 1.68)	1.20 (0.87, 1.65)	1.17 (0.83, 1.66)	0.40
Triglycerides (104.0, 143.0, 192.0)
Unadjusted (case/control pairs=727)	1.0	1.19 (0.88, 1.62)	1.45 (1.07, 1.96)	1.93 (1.43, 2.60)	<0.001
Adjusted (case/control pairs=727)	1.0	1.19 (0.86, 1.64)	1.34 (0.97, 1.85)	1.56 (1.13, 2.17)	<0.01
HDL cholesterol (48.0, 58.0, 70.0)
Unadjusted (case/control pairs=726)	1.0	0.90 (0.68, 1.18)	0.75 (0.56, 1.00)	0.65 (0.48, 0.88)	<0.01
Adjusted (case/control pairs=726)	1.0	0.99 (0.73, 1.32)	0.95 (0.69, 1.29)	0.82 (0.59, 1.16)	0.28
HDL particle number (27.8, 32.0, 36.6)
Unadjusted (case/control pairs=686)	1.0	0.94 (0.69, 1.30)	1.09 (0.80, 1.48)	0.84 (0.60, 1.18)	0.54
Adjusted (case/control pairs=686)	1.0	0.97 (0.69, 1.38)	1.19 (0.85, 1.67)	0.90 (0.63, 1.30)	0.88
HDL size (8.6, 9.1, 9.4)
Unadjusted (case/control pairs=686)	1.0	0.83 (0.62, 1.11)	0.86 (0.64, 1.15)	0.65 (0.47, 0.89)	0.02
Adjusted (case/control pairs=686)	1.0	1.00 (0.72, 1.37)	1.14 (0.83, 1.58)	0.95 (0.66, 1.36)	0.95
IDL particle number (30.0, 60.0, 101.0)
Unadjusted (case/control pairs=686)	1.0	1.18 (0.88, 1.58)	1.38 (1.02, 1.87)	1.55 (1.14, 2.10)	<0.01
Adjusted (case/control pairs=686)	1.0	1.12 (0.81, 1.53)	1.33 (0.96, 1.85)	1.46 (1.04, 2.04)	0.02
LDL cholesterol (114.0, 137.8, 164.4)
Unadjusted (case/control pairs=706)	1.0	1.08 (0.81, 1.45)	1.11 (0.81, 1.50)	1.03 (0.76, 1.41)	0.82
Adjusted (case/control pairs=706)	1.0	1.09 (0.79, 1.49)	1.15 (0.83, 1.61)	0.94 (0.67, 1.32)	0.84
LDL particle number (1226.0, 1457.5, 1721.0)
Unadjusted (case/control pairs=686)	1.0	1.23 (0.90, 1.68)	1.30 (0.95, 1.77)	1.64 (1.20, 2.23)	<0.01
Adjusted (case/control pairs=686)	1.0	1.13 (0.81, 1.59)	1.11 (0.79, 1.56)	1.23 (0.88, 1.73)	0.28
LDL size (20.8, 21.3, 21.7)
Unadjusted (case/control pairs=686)	1.0	0.88 (0.66, 1.16)	0.83 (0.62, 1.13)	0.76 (0.56, 1.03)	0.07
Adjusted (case/control pairs=686)	1.0	1.04 (0.76, 1.42)	1.04 (0.75, 1.45)	0.96 (0.70, 1.33)	0.85
VLDL triglyceride (51.0, 80.0, 122.0)
Unadjusted (case/control pairs=686)	1.0	0.96 (0.70, 1.32)	1.25 (0.91, 1.72)	1.60 (1.18, 2.17)	<0.001
Adjusted (case/control pairs=686)	1.0	0.95 (0.68, 1.32)	1.14 (0.81, 1.61)	1.28 (0.91, 1.79)	0.09
VLDL particle number (57.3, 81.8, 106.7)
Unadjusted (case/control pairs=686)	1.0	1.06 (0.79, 1.43)	1.05 (0.77, 1.45)	1.44 (1.07, 1.94)	0.02
Adjusted (case/control pairs=686)	1.0	1.04 (0.76, 1.43)	1.00 (0.71, 1.41)	1.16 (0.84, 1.61)	0.41
VLDL size (40.4, 44.7, 50.8)
Unadjusted (case/control pairs=686)	1.0	1.44 (1.05, 1.98)	1.55 (1.13, 2.11)	2.04 (1.48, 2.82)	<0.001
Adjusted (case/control pairs=686)	1.0	1.34 (0.96, 1.89)	1.26 (0.90, 1.77)	1.59 (1.10, 2.28)	0.03
Lipoprotein (a) (5.0, 11.0, 27.0)
Unadjusted (case/control pairs=700)	1.0	0.99 (0.73,1.33)	0.85 (0.63, 1.16)	1.14 (0.85, 1.54)	0.58
Adjusted (case/control pairs=700)	1.0	0.95 (0.69, 1.31)	0.92 (0.66, 1.27)	1.16 (0.84, 1.59)	0.45

All unadjusted models conditioned on age and race

All adjusted models conditioned on age and race, and additionally adjusted for smoking status, body mass index, systolic blood pressure, use of anti-hypertensive medication, diabetes, and physical activity

Each row is a separate model with stroke as the outcome which included quartiles of that specific biomarker

Biomarker quartile cut-points were based on all available controls