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. 1976 Jun;18(3):819–823. doi: 10.1128/jvi.18.3.819-823.1976

Fluorosugars inhibit biological properties of different enveloped viruses.

M F Schmidt, R T Schwarz, H Ludwig
PMCID: PMC354779  PMID: 178923

Abstract

Both 2-deoxy-2-fluoro-D-glucose and 2-deoxy-2-fluoro-D-mannose were found to be potent inhibitors of the synthesis of infectious Semliki forest and fowl plague virus in chicken embryo cells and also of pseudorabies virus grown in rabbit kidney cells. It was found that the pseudorabies virus-mediated cell fusion and the synthesis of functional hemagglutinin of fowl plague virus were blocked. In all cases the 2-deoxy-2-fluoro-D-mannose-caused inhibition was stronger than the 2-deoxy-2-fluoro-D-glucose- or 2-deoxy-D-glucose-mediated blocks. Studies on the virus-specified proteins from Semiliki forest virus-infected cells grown in the presence of the inhibitors show that the target of the fluorosugar action, parallel to the well-studied effects of 2-deoxy-D-glucose, is the glycoprotein biosynthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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