Abstract
Seven murine leukemia virus field isolates (uncloned) from wild mice (Musmusculus) of four widely separated areas in southern California show an unusually wide in vitro host range. They replicate well in human, feline, canine, guinea pig, rabbit, rat, and mouse cells, whereas bovine, hamster, and avian cells are resistant. Since this host range includes that of both mouse tropic (ecotropic) and xenotropic murine leukemia viruses, they are designated as "amphotropic". No purely xenotropic virus component is detectable in these field isolates. They may represent the "wild" or ancestral viruses from which the ecotropic and xenotrophic murine leukemia virus strains of laboratory mice have been derived.
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- Duesberg P. H., Robinson W. S. Nucleic acid and proteins isolated from the Rauscher mouse leukemia virus (MLV). Proc Natl Acad Sci U S A. 1966 Jan;55(1):219–227. doi: 10.1073/pnas.55.1.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fischinger P. J., Nomura S., Bolognesi D. P. A novel murine oncornavirus with dual eco- and xenotropic properties. Proc Natl Acad Sci U S A. 1975 Dec;72(12):5150–5155. doi: 10.1073/pnas.72.12.5150. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gardner M. B., Henderson B. E., Estes J. D., Rongey R. W., Casagrande J., Pike M., Huebner R. J. The epidemiology and virology of C-type virus-associated hematological cancers and related diseases in wild mice. Cancer Res. 1976 Feb;36(2 Pt 2):574–581. [PubMed] [Google Scholar]
- Gardner M. B., Henderson B. E., Officer J. E., Rongey R. W., Parker J. C., Oliver C., Estes J. D., Huebner R. J. A spontaneous lower motor neuron disease apparently caused by indigenous type-C RNA virus in wild mice. J Natl Cancer Inst. 1973 Oct;51(4):1243–1254. doi: 10.1093/jnci/51.4.1243. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gardner M. B., Henderson B. E., Rongey R. W., Estes J. D., Huebner R. J. Spontaneous tumors of aging wild house mice. Incidence, pathology, and C-type virus expression. J Natl Cancer Inst. 1973 Mar;50(3):719–734. doi: 10.1093/jnci/50.3.719. [DOI] [PubMed] [Google Scholar]
- Gardner M. B., Officer J. E., Rongey R. W., Charman H. P., Hartley J. W., Estes J. D., Huebner R. J. C-type RNA tumor virus in wild house mice (Mus musculus). Bibl Haematol. 1973;39:335–344. doi: 10.1159/000427860. [DOI] [PubMed] [Google Scholar]
- Gilden R. V., Oroszlan S., Huebner R. J. Coexistence of intraspecies and interspecies specific antigenic determinants on the major structural polypeptide of mammalian C-type viruses. Nat New Biol. 1971 May 26;231(21):107–108. doi: 10.1038/newbio231107a0. [DOI] [PubMed] [Google Scholar]
- Hartley J. W., Rowe W. P., Capps W. I., Huebner R. J. Complement fixation and tissue culture assays for mouse leukemia viruses. Proc Natl Acad Sci U S A. 1965 May;53(5):931–938. doi: 10.1073/pnas.53.5.931. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hartley J. W., Rowe W. P. Clonal cells lines from a feral mouse embryo which lack host-range restrictions for murine leukemia viruses. Virology. 1975 May;65(1):128–134. doi: 10.1016/0042-6822(75)90013-6. [DOI] [PubMed] [Google Scholar]
- Hartley J. W., Rowe W. P. Naturally occurring murine leukemia viruses in wild mice: characterization of a new "amphotropic" class. J Virol. 1976 Jul;19(1):19–25. doi: 10.1128/jvi.19.1.19-25.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hartley J. W., Rowe W. P. Production of altered cell foci in tissue culture by defective Moloney sarcoma virus particles. Proc Natl Acad Sci U S A. 1966 Apr;55(4):780–786. doi: 10.1073/pnas.55.4.780. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henderson B. E., Gardner M. B., Gilden R. V., Estes J. D., Huebner R. J. Prevention of lower limb paralysis by neutralization of type-C RNA virus in wild mice. J Natl Cancer Inst. 1974 Oct;53(4):1091–1092. doi: 10.1093/jnci/53.4.1091. [DOI] [PubMed] [Google Scholar]
- Huebner R. J., Hartley J. W., Rowe W. P., Lane W. T., Capps W. I. Rescue of the defective genome of Moloney sarcoma virus from a noninfectious hamster tumor and the production of pseudotype sarcoma viruses with various murine leukemia viruses. Proc Natl Acad Sci U S A. 1966 Oct;56(4):1164–1169. doi: 10.1073/pnas.56.4.1164. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jainchill J. L., Aaronson S. A., Todaro G. J. Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells. J Virol. 1969 Nov;4(5):549–553. doi: 10.1128/jvi.4.5.549-553.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kelloff G. J., Hatanaka M., Gilden R. V. Assay of C-type virus infectivity by measurement of RNA-dependent DNA polymerase activity. Virology. 1972 Apr;48(1):266–269. doi: 10.1016/0042-6822(72)90135-3. [DOI] [PubMed] [Google Scholar]
- Klement V., Nicolson M. O., Huebner R. J. Rescue of the genome of focus forming virus from rat non-productive lines by 5'-bromodeoxyruidine. Nat New Biol. 1971 Nov 3;234(44):12–14. doi: 10.1038/newbio234012a0. [DOI] [PubMed] [Google Scholar]
- Klement V., Rowe W. P., Hartley J. W., Pugh W. E. Mixed culture cytopathogenicity: a new test for growth of murine leukemia viruses in tissue culture. Proc Natl Acad Sci U S A. 1969 Jul;63(3):753–758. doi: 10.1073/pnas.63.3.753. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levy J. A. Autoimmunity and neoplasia. The possible role of C-type viruses. Am J Clin Pathol. 1974 Aug;62(2):258–280. doi: 10.1093/ajcp/62.2.258. [DOI] [PubMed] [Google Scholar]
- Levy J. A. Xenotropic viruses: murine leukemia viruses associated with NIH Swiss, NZB, and other mouse strains. Science. 1973 Dec 14;182(4117):1151–1153. doi: 10.1126/science.182.4117.1151. [DOI] [PubMed] [Google Scholar]
- McAllister R. M., Melnyk J., Finkelstein J. Z., Adams E. C., Jr, Gardner M. B. Cultivation in vitro of cells derived from a human rhabdomyosarcoma. Cancer. 1969 Sep;24(3):520–526. doi: 10.1002/1097-0142(196909)24:3<520::aid-cncr2820240313>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
- Officer J. E., Tecson N., Estes J. D., Fontanilla E., Rongey R. W., Gardner M. B. Isolation of a neurotropic type C virus. Science. 1973 Sep 7;181(4103):945–947. doi: 10.1126/science.181.4103.945. [DOI] [PubMed] [Google Scholar]
- Oroszlan S., Fisher C. L., Stanley T. B., Gilden R. V. Proteins of the murine C-type RNA tumour viruses: isolation of a group-specific antigen by isoelectric focusing. J Gen Virol. 1970 Jul;8(1):1–10. doi: 10.1099/0022-1317-8-1-1. [DOI] [PubMed] [Google Scholar]
- Pal B. K., Wright M., Officer J. E., Gardner M. B., Roy-Burman P. Subviral components of a wild mouse embryo-derived type C oncornavirus. Virology. 1973 Nov;56(1):189–197. doi: 10.1016/0042-6822(73)90298-5. [DOI] [PubMed] [Google Scholar]
- Pincus T., Hartley J. W., Rowe W. P. A major genetic locus affecting resistance to infection with murine leukemia viruses. I. Tissue culture studies of naturally occurring viruses. J Exp Med. 1971 Jun 1;133(6):1219–1233. doi: 10.1084/jem.133.6.1219. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rasheed S., Nelson-Rees W. A., Toth E. M., Arnstein P., Gardner M. B. Characterization of a newly derived human sarcoma cell line (HT-1080). Cancer. 1974 Apr;33(4):1027–1033. doi: 10.1002/1097-0142(197404)33:4<1027::aid-cncr2820330419>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
- Rongey R. W., Hlavackova A., Lara S., Estes J., Gardner M. B. Types B and C RNA virus in breast tissue and milk of wild mice. J Natl Cancer Inst. 1973 Jun;50(6):1581–1589. doi: 10.1093/jnci/50.6.1581. [DOI] [PubMed] [Google Scholar]
- Rowe W. P., Pugh W. E., Hartley J. W. Plaque assay techniques for murine leukemia viruses. Virology. 1970 Dec;42(4):1136–1139. doi: 10.1016/0042-6822(70)90362-4. [DOI] [PubMed] [Google Scholar]
- Wallace R. E., Vasington P. J., Petricciani J. C., Hopps H. E., Lorenz D. E., Kadanka Z. Development and characterization of cell lines from subhuman primates. In Vitro. 1973 Mar-Apr;8(5):333–341. doi: 10.1007/BF02619057. [DOI] [PubMed] [Google Scholar]