Table 1.

Characteristics of the Pre-RA cases in the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHS2) Cohorts

	NHS	NHSII
	N=76	N=11
Time from blood draw until RA diagnosis, years (± SD)	6.2 (3.5)	1.9 (0.6)
Anti-CCP antibody positive at blood draw, (%)	21 (27.6)	4 (36.4)
HLA-DRB1 shared-epitope positive*, (%)	54 (71.1)	6 (54.5)
Age at diagnosis, years (±SD)	62.6 (8.2)	46.0 (5.5)
Number of ACR criteria at diagnosis, (±SD)	4.5 (0.8)	4.2 (0.6)
Rheumatoid factor present at RA diagnosis, (%)	42 (55.3)	5 (45.5)
Radiographic erosions present at RA diagnosis, (%)	17 (22.4)	2 (18.2)
Rheumatoid nodules present at RA diagnosis, (%)	10 (13.2)	0 (0)
Hand arthritis at diagnosis, (%)	75 (99)	11 (100)

^*one or more shared-epitope copies