Abstract
Two type C viruses with new antigenic and biological properties were isolated by co-cultivating secondary cell strains established from the kidneys of a baboon (Papio papio) and a patas monkey (Erythrocebus patas) with mink cells non-productively transformed by Kirsten sarcoma virus. Both new isolates (designated PP-1R and EP-1R) contain major structural proteins (p30) that are immunologically most closely related to the p30 proteins of feline leukemia viruses. The reverse transcriptases of both viruses, although antigenically related to polymerases of murine and rat type C viruses, are distinct from those of previously described type C viral groups. Both PP-1R and EP-1R can be transmitted to canine and feline cells and to sarcoma virus-transformed, but not normal, mink cells. Both viruses contain RNA genomes partially homologous to those of endogenous mouse and rat type C viruses and the Kirsten sarcoma virus. In addition, the RNA of PP-1R contains a portion of the nucleic acid sequences found in a type C virus isolated from the baboon species P. papio. We propose that both new isolates are genetic recombinants formed between endogenous primate type C viral genomes and sequences found in Kirsten sarcoma-transformed mink cells.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aaronson S. A., Weaver C. A. Characterization of murine sarcoma virus (Kirsten) transformation of mouse and human cells. J Gen Virol. 1971 Nov;13(2):245–252. doi: 10.1099/0022-1317-13-2-245. [DOI] [PubMed] [Google Scholar]
- Ando T. A nuclease specific for heat-denatured DNA in isolated from a product of Aspergillus oryzae. Biochim Biophys Acta. 1966 Jan 18;114(1):158–168. doi: 10.1016/0005-2787(66)90263-2. [DOI] [PubMed] [Google Scholar]
- Beemon K., Duesberg P., Vogt P. Evidence for crossing-over between avian tumor viruses based on analysis of viral RNAs. Proc Natl Acad Sci U S A. 1974 Oct;71(10):4254–4258. doi: 10.1073/pnas.71.10.4254. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Benveniste R. E., Heinemann R., Wilson G. L., Callahan R., Todaro G. J. Detection of baboon type C viral sequences in various primate tissues by molecular hybridization. J Virol. 1974 Jul;14(1):56–67. doi: 10.1128/jvi.14.1.56-67.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Benveniste R. E., Lieber M. M., Livingston D. M., Sherr C. J., Todaro G. J., Kalter S. S. Infectious C-type virus isolated from a baboon placenta. Nature. 1974 Mar 1;248(5443):17–20. doi: 10.1038/248017a0. [DOI] [PubMed] [Google Scholar]
- Benveniste R. E., Sherr C. J., Todaro G. J. Evolution of type C viral genes: origin of feline leukemia virus. Science. 1975 Nov 28;190(4217):886–888. doi: 10.1126/science.52892. [DOI] [PubMed] [Google Scholar]
- Benveniste R. E., Todaro G. J. Evolution of C-type viral genes: inheritance of exogenously acquired viral genes. Nature. 1974 Dec 6;252(5483):456–459. doi: 10.1038/252456a0. [DOI] [PubMed] [Google Scholar]
- Benveniste R. E., Todaro G. J. Evolution of type C viral genes: I. Nucleic acid from baboon type C virus as a measure of divergence among primate species. Proc Natl Acad Sci U S A. 1974 Nov;71(11):4513–4518. doi: 10.1073/pnas.71.11.4513. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Benveniste R. E., Todaro G. J. Evolution of type C viral genes: evidence for an Asian origin of man. Nature. 1976 May 13;261(5556):101–108. doi: 10.1038/261101a0. [DOI] [PubMed] [Google Scholar]
- Benveniste R. E., Todaro G. J. Homology between type-C viruses of various species as determined by molecular hybridization. Proc Natl Acad Sci U S A. 1973 Dec;70(12):3316–3320. doi: 10.1073/pnas.70.12.3316. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Birnstiel M. L., Sells B. H., Purdom I. F. Kinetic complexity of RNA molecules. J Mol Biol. 1972 Jan 14;63(1):21–39. doi: 10.1016/0022-2836(72)90519-0. [DOI] [PubMed] [Google Scholar]
- Collett M. S., Faras A. J. In vitro transcription of DNA from the 70S RNA of Rous sarcoma virus: identification and characterization of various size classes of DNA transcripts. J Virol. 1975 Nov;16(5):1220–1228. doi: 10.1128/jvi.16.5.1220-1228.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Duesberg P. H., Vogt P. K. RNA species obtained from clonal lines of avian sarcoma and from avian leukosis virus. Virology. 1973 Jul;54(1):207–219. doi: 10.1016/0042-6822(73)90130-x. [DOI] [PubMed] [Google Scholar]
- Duesberg P., Vogt P. K., Beemon K., Lai M. Avian RNA tumor viruses: mechanism of recombination and complexity of the genome. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):847–857. doi: 10.1101/sqb.1974.039.01.099. [DOI] [PubMed] [Google Scholar]
- Fischinger P. J., Nomura S., Bolognesi D. P. A novel murine oncornavirus with dual eco- and xenotropic properties. Proc Natl Acad Sci U S A. 1975 Dec;72(12):5150–5155. doi: 10.1073/pnas.72.12.5150. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GREENWOOD F. C., HUNTER W. M., GLOVER J. S. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem J. 1963 Oct;89:114–123. doi: 10.1042/bj0890114. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gardner M. B., Arnstein P., Johnson E., Rongey R. W., Charman H. P., Huebner R. J. Feline sarcoma virus tumor induction in cats and dogs. J Am Vet Med Assoc. 1971 Mar 15;158(6 Suppl):1046+–1046+. [PubMed] [Google Scholar]
- Giard D. J., Aaronson S. A., Todaro G. J., Arnstein P., Kersey J. H., Dosik H., Parks W. P. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst. 1973 Nov;51(5):1417–1423. doi: 10.1093/jnci/51.5.1417. [DOI] [PubMed] [Google Scholar]
- Goldberg R. J., Scolnick E. M., Parks W. P., Yakovleva L. A., Lapin B. A. Isolation of a primate type-C virus from a lymphomatous baboon. Int J Cancer. 1974 Dec 15;14(6):722–730. doi: 10.1002/ijc.2910140605. [DOI] [PubMed] [Google Scholar]
- Hanafusa T., Hanafusa H., Miyamoto T. Recovery of a new virus from apparently normal chick cells by infection with avian tumor viruses. Proc Natl Acad Sci U S A. 1970 Dec;67(4):1797–1803. doi: 10.1073/pnas.67.4.1797. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hartley J. W., Rowe W. P. Clonal cells lines from a feral mouse embryo which lack host-range restrictions for murine leukemia viruses. Virology. 1975 May;65(1):128–134. doi: 10.1016/0042-6822(75)90013-6. [DOI] [PubMed] [Google Scholar]
- Hayward W. S., Hanafusa H. Recombination between endogenous and exogenous RNA tumor virus genes as analyzed by nucleic acid hybridization. J Virol. 1975 Jun;15(6):1367–1377. doi: 10.1128/jvi.15.6.1367-1377.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henderson I. C., Lieber M. M., Todaro G. J. Mink cell line Mv 1 Lu (CCL 64). Focus formation and the generation of "nonproducer" transformed cell lines with murine and feline sarcoma viruses. Virology. 1974 Jul;60(1):282–287. doi: 10.1016/0042-6822(74)90386-9. [DOI] [PubMed] [Google Scholar]
- Huu Duc-Nguyen, Rosenblum E. N., Zeigel R. F. Persistent infection of a rat kidney cell line with Rauscher murine leukemia virus. J Bacteriol. 1966 Oct;92(4):1133–1140. doi: 10.1128/jb.92.4.1133-1140.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Joho R. H., Billeter M. A., Weissmann C. Mapping of biological functions on RNA of avian tumor viruses: location of regions required for transformation and determination of host range. Proc Natl Acad Sci U S A. 1975 Dec;72(12):4772–4776. doi: 10.1073/pnas.72.12.4772. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Junghans R. P., Duesberg P. H., Knight C. A. In vitro synthesis of full-length DNA transcripts of Rous sarcoma virus RNA by viral DNA polymerase. Proc Natl Acad Sci U S A. 1975 Dec;72(12):4895–4899. doi: 10.1073/pnas.72.12.4895. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Lieber M. M., Benveniste R. E., Livingston D. M., Todaro G. J. Mammalian cells in culture frequently release type C viruses. Science. 1973 Oct 5;182(4107):56–59. doi: 10.1126/science.182.4107.56. [DOI] [PubMed] [Google Scholar]
- Lieber M. M., Benveniste R. E., Sherr C. J., Todaro G. J. Isolation of a type C virus (FS-1) from the European Wildcat (Felis sylvestris). Virology. 1975 Jul;66(1):117–127. doi: 10.1016/0042-6822(75)90183-x. [DOI] [PubMed] [Google Scholar]
- Lieber M. M., Sherr C. J., Todaro G. J., Benveniste R. E., Callahan R., Coon H. G. Isolation from the asian mouse Mus caroli of an endogenous type C virus related to infectious primate type C viruses. Proc Natl Acad Sci U S A. 1975 Jun;72(6):2315–2319. doi: 10.1073/pnas.72.6.2315. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lieber M. M., Sherr C. J., Todaro G. J. S-tropic murine type-C viruses: frequency of isolation from continuous cell lines, leukemia virus preparations and normal spleens. Int J Cancer. 1974 May 15;13(5):587–598. doi: 10.1002/ijc.2910130503. [DOI] [PubMed] [Google Scholar]
- Maisel J., Scolnick E. M., Duesberg P. Base sequence differences between the RNA components of Harvey sarcoma virus. J Virol. 1975 Sep;16(3):749–753. doi: 10.1128/jvi.16.3.749-753.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McAllister R. M., Nicolson M., Gardner M. B., Rongey R. W., Rasheed S., Sarma P. S., Huebner R. J., Hatanaka M., Oroszlan S., Gilden R. V. C-type virus released from cultured human rhabdomyosarcoma cells. Nat New Biol. 1972 Jan 5;235(53):3–6. doi: 10.1038/newbio235003a0. [DOI] [PubMed] [Google Scholar]
- Parks W. P., Scolnick E. M. Radioimmunoassay of mammalian type-C viral proteins: interspecies antigenic reactivities of the major internal polypeptide. Proc Natl Acad Sci U S A. 1972 Jul;69(7):1766–1770. doi: 10.1073/pnas.69.7.1766. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RAUSCHER F. J. A virus-induced disease of mice characterized by erythrocytopoiesis and lymphoid leukemia. J Natl Cancer Inst. 1962 Sep;29:515–543. [PubMed] [Google Scholar]
- Rickard C. G., Post J. E., Noronha F., Barr L. M. A transmissible virus-induced lymphocytic leukemia of the cat. J Natl Cancer Inst. 1969 Jun;42(6):987–1014. [PubMed] [Google Scholar]
- Rothenberg E., Baltimore D. Synthesis of long, representative DNA copies of the murine RNA tumor virus genome. J Virol. 1975 Jan;17(1):168–174. doi: 10.1128/jvi.17.1.168-174.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scolnic E. M., Goldberg R. J., Parks W. P. A biochemical and genetic analysis of mammalian RNA-containing sarcoma viruses. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):885–895. doi: 10.1101/sqb.1974.039.01.103. [DOI] [PubMed] [Google Scholar]
- Scolnick E. M., Maryak J. M., Parks W. P. Levels of rat cellular RNA homologous to either Kirsten sarcoma virus or rat type-C virus in cell lines derived from Osborne-Mendel rats. J Virol. 1974 Dec;14(6):1435–1444. doi: 10.1128/jvi.14.6.1435-1444.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scolnick E. M., Parks W. P., Livingston D. M. Radioimmunoassay of mammalian type C viral proteins. I. Species specific reactions of murine and feline viruses. J Immunol. 1972 Sep;109(3):570–577. [PubMed] [Google Scholar]
- Scolnick E. M., Rands E., Williams D., Parks W. P. Studies on the nucleic acid sequences of Kirsten sarcoma virus: a model for formation of a mammalian RNA-containing sarcoma virus. J Virol. 1973 Sep;12(3):458–463. doi: 10.1128/jvi.12.3.458-463.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sherr C. J., Fedele L. A., Benveniste R. E., Todaro G. J. Interspecies antigenic determinants of the reverse transcriptases and p30 proteins of mammalian type C viruses. J Virol. 1975 Jun;15(6):1440–1448. doi: 10.1128/jvi.15.6.1440-1448.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sherr C. J., Todaro G. J. Radioimmunoassay of the major group specific protein of endogenous baboon type C viruses: relation to the RD-114-CCC group and detection of antigen in normal baboon tissues. Virology. 1974 Sep;61(1):168–181. doi: 10.1016/0042-6822(74)90252-9. [DOI] [PubMed] [Google Scholar]
- Stephenson J. R., Anderson G. R., Tronick S. R., Aaronson S. A. Evidence for genetic recombination between endogenous and exogenous mouse RNA type C viruses. Cell. 1974 Jun;2(2):87–94. doi: 10.1016/0092-8674(74)90096-8. [DOI] [PubMed] [Google Scholar]
- Sweet C. S., Kadowitz P. J., Brody M. J. Another humoral substance that enhances adrenergic responsiveness during acute renal ischaemia. Nature. 1971 May 28;231(5300):263–265. doi: 10.1038/231263a0. [DOI] [PubMed] [Google Scholar]
- Teitz Y., Lennette E. H., Oshiro L. S., Cremer N. E. Release of C-type particles from normal rat thymus cultures and those infected with Moloney leukemia virus. J Natl Cancer Inst. 1971 Jan;46(1):11–23. [PubMed] [Google Scholar]
- Theilen G. H., Gould D., Fowler M., Dungworth D. L. C-type virus in tumor tissue of a woolly monkey (Lagothrix spp.) with fibrosarcoma. J Natl Cancer Inst. 1971 Oct;47(4):881–889. [PubMed] [Google Scholar]
- Todaro G. J., Arnstein P., Parks W. P., Lennette E. H., Huebner R. J. A type-C virus in human rhabdomyosarcoma cells after inoculation into NIH Swiss mice treated with antithymocyte serum. Proc Natl Acad Sci U S A. 1973 Mar;70(3):859–862. doi: 10.1073/pnas.70.3.859. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Todaro G. J., Benveniste R. E., Callahan R., Lieber M. M., Sherr C. J. Endogenous primate and feline type C viruses. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):1159–1168. doi: 10.1101/sqb.1974.039.01.133. [DOI] [PubMed] [Google Scholar]
- Todaro G. J., Benveniste R. E., Lieber M. M., Sherr C. J. Characterization of a type C virus released from the porcine cell line PK(15). Virology. 1974 Mar;58(1):65–74. doi: 10.1016/0042-6822(74)90141-x. [DOI] [PubMed] [Google Scholar]
- Todaro G. J., Sherr C. J., Benveniste R. E. Baboons and their close relatives are unusual among primates in their ability to release nondefective endogenous type C viruses. Virology. 1976 Jul 1;72(1):278–282. doi: 10.1016/0042-6822(76)90331-7. [DOI] [PubMed] [Google Scholar]
- Todaro G. J., Sherr C. J., Benveniste R. E., Lieber M. M., Melnick J. L. Type C viruses of baboons: isolation from normal cell cultures. Cell. 1974 May;2(1):55–61. doi: 10.1016/0092-8674(74)90008-7. [DOI] [PubMed] [Google Scholar]
- Todaro G. J. Spontaneous release of type C viruses from clonal lines of spontaneously transformed Blab-3T3 cells. Nat New Biol. 1972 Nov 29;240(100):157–160. doi: 10.1038/newbio240157a0. [DOI] [PubMed] [Google Scholar]
- Tsuchida N., Gilden R. V., Hatanaka M. Size of virus-specific RNA in B-34, a hamster tumor cell producing nucleic acids of type C viruses from three species. J Virol. 1975 Oct;16(4):832–837. doi: 10.1128/jvi.16.4.832-837.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wallace R. E., Vasington P. J., Petricciani J. C., Hopps H. E., Lorenz D. E., Kadanka Z. Development and characterization of cell lines from subhuman primates. In Vitro. 1973 Mar-Apr;8(5):333–341. doi: 10.1007/BF02619057. [DOI] [PubMed] [Google Scholar]
- Weiss R. A., Mason W. S., Vogt P. K. Genetic recombinants and heterozygotes derived from endogenous and exogenous avian RNA tumor viruses. Virology. 1973 Apr;52(2):535–552. doi: 10.1016/0042-6822(73)90349-8. [DOI] [PubMed] [Google Scholar]
- Wong P. K., McCarter J. A. Genetic studies of temperature-sensitive mutants of Moloney-murine leukemia virus. Virology. 1973 Jun;53(2):319–326. doi: 10.1016/0042-6822(73)90209-2. [DOI] [PubMed] [Google Scholar]
- Wyke J. A., Bell J. G., Beamand J. A. Genetic recombination among temperature-sensitive mutnats of Rous sarcoma virus. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):897–905. doi: 10.1101/sqb.1974.039.01.104. [DOI] [PubMed] [Google Scholar]