Skip to main content
NCBI home page
Journal of Virology logoLink to Journal of Virology
. 1976 Nov;20(2):539–542. doi: 10.1128/jvi.20.2.539-542.1976

Two adenovirus type 2-simian virus 40 hybrid populations that contain the entire SV40 genome differ in their ability to induce SV40 transplantation immunity in hamsters but not in mice.

S S Tevethia, A M Lewis Jr
PMCID: PMC355023  PMID: 185429

Abstract

Ad2++ HEY and Ad2++ LEY are two adenovirus 2(Ad2)-simian virus 40 (SV40) hybrids distinguished by differences in the efficiency with which they produce SV40 progeny in lytically infected African green monkey kidney cells. These virus populations are composed of nonhybrid Ad2 and hybrid virions, the majority of which contain more than 1 unit of SV40 DNA. The Ad2++ HEY and LEY populations also differ in their ability to induce SV40 transplantation immunity in rodents. Only Ad2++ HEY induces SV40 transplantation immunity in hamsters, whereas both viruses induce significant SV40 transplantation immunity in adult BALB/c mice.

Full text

PDF
539

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Altstein A. D., Deichman G. I., Dodonova N. N. Induction of specific antitumor immunity in hamsters with hydroxylamine-inactivated SV40 virus. Virology. 1966 Dec;30(4):747–749. doi: 10.1016/0042-6822(66)90183-8. [DOI] [PubMed] [Google Scholar]
  2. Hoggan M. D., Blacklow N. R., Rowe W. P. Studies of small DNA viruses found in various adenovirus preparations: physical, biological, and immunological characteristics. Proc Natl Acad Sci U S A. 1966 Jun;55(6):1467–1474. doi: 10.1073/pnas.55.6.1467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Kelly T. J., Jr, Lewis A. M., Jr, Levine A. S., Siegel S. Structure of two adenovirus-simian virus 40 hybrids which contain the entire SV40 genome. J Mol Biol. 1974 Oct 15;89(1):113–126. doi: 10.1016/0022-2836(74)90165-x. [DOI] [PubMed] [Google Scholar]
  4. Kelly T. J., Jr, Lewis A. M., Jr Use of nondefective adenovirus-simian virus 40 hybrids for mapping the simian virus 40 genome. J Virol. 1973 Sep;12(3):643–652. doi: 10.1128/jvi.12.3.643-652.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kelly T. J. Structure of the DNA of the adenovirus 7-simian virus 40 hybrid, e46, by electron microscopy. J Virol. 1975 May;15(5):1267–1272. doi: 10.1128/jvi.15.5.1267-1272.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lewis A. M., Jr, Rowe W. P. Isolation of two plaque variants from the adenovirus type 2-simian virus 40 hybrid population which differ in their efficiency in yielding simian virus 40. J Virol. 1970 Apr;5(4):413–420. doi: 10.1128/jvi.5.4.413-420.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lewis A. M., Jr, Rowe W. P. Studies of nondefective Adenovirus 2-Simian virus 40 hybrid viruses. 8. Association of Simian virus 40 transplantation antigen with a specific region of the early viral genome. J Virol. 1973 Oct;12(4):836–840. doi: 10.1128/jvi.12.4.836-840.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Rapp F., Butel J. S., Tevethia S. S., Melnick J. L. Comparison of ability of defective foreign genomes (PARA and MAC) carried by human adenoviruses to induce SV40 transplantation immunity. J Immunol. 1967 Aug;99(2):386–391. [PubMed] [Google Scholar]
  9. Rapp F., Tevethia S. S., Melnick J. L. Papovavirus SV40 transplantation immunity conferred by an adenovirus-SV40 hybrid. J Natl Cancer Inst. 1966 Apr;36(4):703–708. doi: 10.1093/jnci/36.4.703. [DOI] [PubMed] [Google Scholar]
  10. Siegel S. E., Patch C. T., Lewis A. M., Jr, Levine A. S. Simian virus 40 DNA replication, transcription, and antigen induction during infection with two adenovirus 2-SV40 hybrids that contain the entire SV40 genome. J Virol. 1975 Jul;16(1):43–52. doi: 10.1128/jvi.16.1.43-52.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Tevethia M. J., Tevethia S. S. Biology of SV40 transplantation antigen (TrAg). I. Demonstration of SV40 TrAg on glutaraldehyde-fixed SV40-infected African green monkey kidney cells. Virology. 1976 Feb;69(2):474–489. doi: 10.1016/0042-6822(76)90478-5. [DOI] [PubMed] [Google Scholar]
  12. Tevethia S. S., Diamandopoulos G. T., Rapp F., Enders J. F. Lack of relationship between virus-specific surface and transplantation antigens in hamster cells transformed by simian papovavirus SV40. J Immunol. 1968 Dec;101(6):1192–1198. [PubMed] [Google Scholar]
  13. Tevethia S. S., MacMillan V. L. Acquisition of malignant properties by SV40-transformed mouse cells: relationship to type-C viral antigen expression. Intervirology. 1974;3(4):269–276. doi: 10.1159/000149763. [DOI] [PubMed] [Google Scholar]
  14. Zarling J. M., Tevethia S. S. Transplantation immunity to simian virus 40-transformed cells in tumor-bearing mice. I. Development of cellular immunity to simian virus 40 tumor-specific transplantation antigens during tumorigenesis by transplanted cells. J Natl Cancer Inst. 1973 Jan;50(1):137–147. doi: 10.1093/jnci/50.1.137. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES