Skip to main content
Journal of Medical Toxicology logoLink to Journal of Medical Toxicology
. 2009 Jun;5(2):80–83. doi: 10.1007/BF03161093

Intra-aortic balloon pump in toxic myocarditis due to aluminum phosphide poisoning

Latha M Siddaiah 1,, Srilakshmi M Adhyapak 1, Santosh M Jaydev 1, Gurappa G Shetty 1, Kiron Varghese 1, Chandrakanth B Patil 1, Shamanna S Iyengar 1
PMCID: PMC3550326  PMID: 19415593

Abstract

Introduction

Aluminum phosphide (ALP) is a pesticide that is highly toxic. It is a mitochondrial toxin that causes death by cardiac and metabolic toxicity. The most ominous effect is cardiac toxicity, which may range from minor electrocardiographic abnormalities to severe depression of cardiac contractility secondary to toxic myocarditis. There is no documented report of the use of Intra-aortic Balloon Pump (IABP) for toxic myocarditis from ALP poisoning, although it has been used effectively for toxic myocarditis due to other toxins.

Case Report

We are reporting a young female who presented with ALP poisoning, in cardiogenic shock due to myocarditis. We used an IABP for cardio-circulatory support until the effects of ALP resolved. She is the only reported survivor of ALP poisoning, presenting with cardiogenic shock.

Discussion

Several reports describe the use of IABP for cardiogenic shock due to toxic myocarditis. There is no report in the medical literature using IABP for cardiogenic shock caused by ALP toxin-induced myocarditis. Our patient presented with cardio-circulatory shock, necessitating the use of inotropes and mechanical ventilation. As she did not improve despite ventilation and maximal doses of inotropes, IABP was used for cardio-circulatory support until the effects of ALP resolved.

Keywords: aluminum phosphide, cardiogenic shock, intra-aortic balloon pump

Full Text

The Full Text of this article is available as a PDF (205.5 KB).

Footnotes

There was no outside funding of any kind used for this study.

References

  • 1.Gupta S, Ahlawat SK. Aluminum phosphide poisoning. A Review. J Toxicol/Clin Toxicol. 1995;33:19–24. doi: 10.3109/15563659509020211. [DOI] [PubMed] [Google Scholar]
  • 2.Hajouji Idrissi M, Oualili L, Abidi K, et al. Severity factors of aluminum phosphide poisoning (Phostoxin) Ann Fr Anesth Reanim. 2006;25:382–385. doi: 10.1016/j.annfar.2005.12.004. [DOI] [PubMed] [Google Scholar]
  • 3.Tripathi SK, Gautam CS, Sharma PL. Clinical pharmacology of aluminium phosphide poisoning. Indian J Pharmacol. 1992;24:134–137. [Google Scholar]
  • 4.Chugh N. Aluminium phosphide. In: Lall SB, editor. Essentials of clinical toxicology. New Delhi: Narosa Publishing House; 1998. pp. 41–46. [Google Scholar]
  • 5.Singh RB, Rastogi SS, Singh DS. Cardiovascular manifestations of aluminum phosphide intoxication. J Assoc Physicians India. 1989;37:590–592. [PubMed] [Google Scholar]
  • 6.Akkouui M, Achur S, Abidi K, et al. Reversible myocardial injury associated with aluminum phosphide poisoning. Clin Toxicol. 2007;45:728–731. doi: 10.1080/15563650701517350. [DOI] [PubMed] [Google Scholar]
  • 7.Shadnia S, Rahimi M, Pajoumand A, et al. Successful treatment of acute aluminium phosphide poisoning: possible benefit of coconut oil. Hum Exp Toxicol. 2005;24(4):215–218. doi: 10.1191/0960327105ht513oa. [DOI] [PubMed] [Google Scholar]
  • 8.Uriel N, Kaluski E, Hendler A, et al. Cardiogenic shock in a young female with multiple sclerosis. Resuscitation. 2006;70(1):153–157. doi: 10.1016/j.resuscitation.2005.11.003. [DOI] [PubMed] [Google Scholar]
  • 9.David JS, Gueugniaud PY, Hepp A, et al. Severe heart failure secondary to 5-fluorouracil and low doses of folinic acid: usefulness of an intra-aortic balloon pump. Crit Care Med. 2000;28(10):3558–3560. doi: 10.1097/00003246-200010000-00038. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Medical Toxicology are provided here courtesy of Springer

RESOURCES