Abstract
Extracts of the bark of the central African treePausinystalia yohimbe contain yohimbine, an indole alkaloid, which is used to treat erectile dysfunction. The reported side effects of over-the-counter preparations of yohimbine include gastrointestinal upset, anxiety, increased blood pressure, headache, agitation, rash, tachycardia, and frequent urination. In this report, we describe a severe case of intractable priapism associated with the ingestion of yohimbe extract. Management required insertion of a proximal cavernosal spongiosum shunt (Quackles shunt) in the operating room.
Keywords: yohimbe, priapism, erectile dysfunction
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Footnotes
Notes: There was no outside funding of any kind used for this study
References
- 1.Guay AT, Spark RF, Jacobson J, et al. Yohimbe treatment of organic erectile dysfunction in a dose-escalation trial. Int J Impot Res. 2002;14:25–31. doi: 10.1038/sj.ijir.3900803. [DOI] [PubMed] [Google Scholar]
- 2.Morales A. Yohimbe in erectile dysfunction: the facts. Int J Impot Res. 2000;12(suppl 1):S70–S74. doi: 10.1038/sj.ijir.3900508. [DOI] [PubMed] [Google Scholar]
- 3.McKay D. Nutrients and botanicals for erectile dysfunction: examining the evidence. Altern Med Rev. 2004;9:4–16. [PubMed] [Google Scholar]
- 4.Ernst E, Pittler MH. Yohimbe for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials. J Urol. 1998;159:433–436. doi: 10.1016/S0022-5347(01)63942-9. [DOI] [PubMed] [Google Scholar]
- 5.Hatzichristou DG, Pescatori ES. Current treatments and emerging therapeutic approaches in male erectile dysfunction. BJU Int. 2001;88(suppl 3):11–17. doi: 10.1046/j.1464-4096.2001.123.x. [DOI] [PubMed] [Google Scholar]
- 6.Adeniyi AA, Brindley GS, Pryor JP, et al. Yohimbe in the treatment of orgasmic dysfunction. Asian J Androl. 2007;9:403–407. doi: 10.1111/j.1745-7262.2007.00276.x. [DOI] [PubMed] [Google Scholar]
- 7.Tam SW, Worcel m, Michael W. Yohimbine: a clinical review. Pharmacol Ther. 2001;91:215–243. doi: 10.1016/S0163-7258(01)00156-5. [DOI] [PubMed] [Google Scholar]