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. 1973 Apr;11(4):610–613. doi: 10.1128/jvi.11.4.610-613.1973

Effect of Isotopic Label on Buoyant Density Determinations of Viral DNA in the Preparative Ultracentrifuge

Enzo Cassai ¹, Steven Bachenheimer ¹

PMCID: PMC355146 PMID: 4349498

Abstract

The buoyant density of herpes simplex virus DNA may be significantly increased by isotopic labeling, particularly with ¹⁴C. The apparent increase in buoyant density may be readily calculated from the specific activity of the DNA and is easily demonstrated by isopycnic centrifugation in both the preparative and analytical centrifuge.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

Kieff E. D., Bachenheimer S. L., Roizman B. Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2. J Virol. 1971 Aug;8(2):125–132. doi: 10.1128/jvi.8.2.125-132.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]

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