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. 1973 Jun;11(6):832–839. doi: 10.1128/jvi.11.6.832-839.1973

Polioviruses, Coxsackieviruses, and Echoviruses: Comparison of the Genomes by RNA Hybridization

Nathaniel A Young 1,2,3
PMCID: PMC355189  PMID: 4351457

Abstract

Hybridization of single-stranded RNA from virions of human enteroviruses with denatured double-stranded RNA from infected cells indicates that a minimum of about 5% of the genome is shared by these viruses. Polynucleotide sequence relationships, furthermore, are consistent with the biologic classification into polioviruses, coxsackieviruses groups A and B, and echoviruses. In general, about 30 to 50% of the nucleotide sequences are shared by different serotypes of virus within each of these major groups, whereas among different groups less than 20% homology is observed. Coxsackievirus B4 appears to be more closely related to echoviruses than to group A coxsackieviruses, whereas polioviruses are only distantly related to any of the other agents.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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