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. 1973 Jun;11(6):856–861. doi: 10.1128/jvi.11.6.856-861.1973

Replication Process of the Parvovirus H-1 I. Kinetics in a Parasynchronous Cell System

Solon L Rhode III 1
PMCID: PMC355192  PMID: 4736535

Abstract

Parasynchronous cultures of hamster embryo cells were used to study some of the events in the replication process of the parvovirus H-1. Synthesis of viral DNA, viral hemagglutinating antigen, and infectious virus were examined. It was found that initiation of DNA synthesis, on which subsequent viral hemagglutinin synthesis was dependent, occurred at a specific time in late S-phase. Production of H-1 viral protein was shown to be sensitive to inhibition by α-amanitin. The implications of these findings are discussed.

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Selected References

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