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. 1973 Jul;12(1):199–201. doi: 10.1128/jvi.12.1.199-201.1973

Mutagenic Effect of Temperature-Sensitive Mutants of Gene 42 (dCMP Hydroxymethylase) of Bacteriophage T4

Che-Shen Chiu 1, G Robert Greenberg 1
PMCID: PMC355246  PMID: 4579822

Abstract

Certain temperature-sensitive mutants of gene 42 of bacteriophage T4 increase the reversion rates of some rII mutants in the same genome by about 4 to 10 times. This effect was usually found at 34 C, an intermediate permissive temperature, but not at 28 C.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernstein H. Reversion of frameshift mutations stimulated by lesions in early function genes of bacteriophage T4. J Virol. 1971 Apr;7(4):460–466. doi: 10.1128/jvi.7.4.460-466.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chiu C. S., Greenberg G. R. Evidence for a possible direct role of dCMP hydroxymethylase in T4 phage DNA synthesis. Cold Spring Harb Symp Quant Biol. 1968;33:351–359. doi: 10.1101/sqb.1968.033.01.041. [DOI] [PubMed] [Google Scholar]
  3. De Waard A., Paul A. V., Lehman I. R. The structural gene for deoxyribonucleic acid polymerase in bacteriophages T4 and T5. Proc Natl Acad Sci U S A. 1965 Oct;54(4):1241–1248. doi: 10.1073/pnas.54.4.1241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Drake J. W., Allen E. F. Antimutagenic DNA polymerases of bacteriophage T4. Cold Spring Harb Symp Quant Biol. 1968;33:339–344. doi: 10.1101/sqb.1968.033.01.039. [DOI] [PubMed] [Google Scholar]
  5. Muzyczka N., Poland R. L., Bessman M. J. Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4. J Biol Chem. 1972 Nov 25;247(22):7116–7122. [PubMed] [Google Scholar]
  6. Speyer J. F., Karam J. D., Lenny A. B. On the role of DNA polymerase in base selection. Cold Spring Harb Symp Quant Biol. 1966;31:693–697. doi: 10.1101/sqb.1966.031.01.088. [DOI] [PubMed] [Google Scholar]
  7. Speyer J. F. Mutagenic DNA polymerase. Biochem Biophys Res Commun. 1965 Oct 8;21(1):6–8. doi: 10.1016/0006-291x(65)90417-1. [DOI] [PubMed] [Google Scholar]
  8. Warner H. R., Barnes J. E. Evidence for a dual role for the bacteriophage T4-induced deoxycytidine triphosphate nucleotidohydrolase. Proc Natl Acad Sci U S A. 1966 Oct;56(4):1233–1240. doi: 10.1073/pnas.56.4.1233. [DOI] [PMC free article] [PubMed] [Google Scholar]

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