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. 1974 Jan;13(1):146–154. doi: 10.1128/jvi.13.1.146-154.1974

Replication of Bacteriophage φX174 DNA in a Temperature-Sensitive dnaC Mutant of Escherichia coli C

Evangelia G Kranias 1, Lawrence B Dumas 1
PMCID: PMC355269  PMID: 4590017

Abstract

Bacteriophage φX174 cannot grow in a temperature-sensitive dnaC mutant of Escherichia coli C at the nonpermissive temperature. The inability to grow is the result of inhibition of virus DNA synthesis. Parental replicative form synthesis is not temperature sensitive. Single-stranded virus DNA continues to be synthesized for at least 45 min after shifting to the nonpermissive temperature late in infection. In contrast, the replication of the replicative form terminates within 5 min after shifting to the nonpermissive temperature.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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