Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Jan 17;62(2):510–518. doi: 10.2337/db12-0294

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

PMC Copyright notice

FIG. 1. — Disruption of PGDPs improves glucose tolerance and enhances insulin secretion. Blood glucose levels (A) and plasma insulin levels (B) in the OGTT in 12- to 15-week-old control (Ctl, Gcg^+/+ and Gcg^gfp/+) and Gcg^gfp/gfp mice (n = 5–6 mice per group). Blood glucose levels (C) and plasma insulin levels (D) in the IPGTT in 11- to 22-week-old mice (n = 9–10 mice per group). E: Glucose-induced insulin secretion from isolated islets. Pancreatic islets were isolated from 5- to 7-month-old control (Gcg^+/+ and Gcg^gfp/+, n = 13–18 in each group) and Gcg^gfp/gfp (n = 8–9 in each group) mice and incubated with the indicated concentration of glucose for 30 min. Insulin secretion is expressed as the ratio of insulin released into the medium relative to insulin content. Values are expressed as means ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001 vs. Ctl. ††P < 0.01. †††P < 0.001 vs. 4.2 mmol/L glucose. #P < 0.05; ##P < 0.01; ###P < 0.001 vs. 2.8 mmol/L glucose.