FIG. 4.

BIM-22493 reduces heart rate and diastolic blood pressure over the course of the treatment. A: Measurements of heart rate after administration of BIM-22493. Heart rate measurements during the normal daytime hours demonstrated that a trend toward reduction in heart rate was seen over the whole period (P = 0.0035). B: Diastolic blood pressure, but not systolic, was reduced in response to the BIM-22493 treatment (P = 0.02). All statistics were performed by repeated-measures ANOVA. *Individually significant by Dunnett post hoc test vs. vehicle. All data points are recorded before surgery, except in cases of week 1 of treatment and week 9 of washout, where data were collected for 48 h postimplantation of BIM-22493 and vehicle respectively.