FIG. 5.

LY2112688 administration results in decreased food intake and increased heart rate. A: LY2112688 reduced average daily food intake similar to BIM-22493 measured over the week of treatment, although not as effectively (P < 0.0001). B: LY2112688 increased heart rate for 2 days after implantation of the minipump, whereas BIM-22493 did not alter heart rate (P < 0.001). All statistics were performed by repeated-measures ANOVA. *Individually significant values by Bonferroni post hoc test from vehicle period. *P < 0.05, **P < 0.01.