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. 1974 Jun;13(6):1331–1337. doi: 10.1128/jvi.13.6.1331-1337.1974

Origin of Reovirus Oligo(A)

C Carter a, C M Stoltzfus a,1, A K Banerjee a, A J Shatkin a
PMCID: PMC355453  PMID: 4833611

Abstract

Reovirus contains about 1,200 molecules per virion of oligo(A) of chain length 10 to 15 nucleotides in addition to the 10 double-stranded genome segments. Virions purified from infected BHK, HeLa, or L cells had similar amounts of oligo(A) of the same composition, indicating that it is a virus-specific product. Although conversion of virions to cores by chymotryptic digestion resulted in an almost complete loss of oligo(A) and a marked decrease in infectivity, the infectivity could be partially restored by adsorbing cores to cells in the presence of Kaopectate. Core-infected cells yielded virions that contained a normal complement of oligo(A). The results indicate that oligo(A) is not essential for infectivity or required as a primer/template for its own synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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