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. 1974 Sep;14(3):451–456. doi: 10.1128/jvi.14.3.451-456.1974

Evidence for a Stable Intermediate in Leukemia Virus Activation in AKR Mouse Embryo Cells

James N Ihle 1, Francis T Kenney 1, Raymond W Tennant 1
PMCID: PMC355537  PMID: 4604455

Abstract

Analysis of the requirement for serum in the activation of the endogenous leukemia virus expression in AKR mouse embryo cells by 5-iododeoxyuridine shows that activation can be dissociated into two discrete serum-dependent events. The first involves incorporation of 5-iododeoxyuridine into DNA and results in the formation of a stable “activation intermediate” resembling the provirus formed during infection of stationary mouse embryo cells with exogenous leukemia virus. The second event, resulting in expression of the activation intermediate as synthesis of virus proteins, requires DNA replication but not 5-iododeoxyuridine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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