Table 2.
Immunogenicity and efficacy of pTC83 iDNA vaccine in BALB/c mice.
| Vaccine | No. of animals |
PRNT80, Titer Range (GMT) |
Challenge dose, s.c.a |
Viremia/ Total(%) |
Viremia Range, Log10PFU/mlb |
Survival, % |
|---|---|---|---|---|---|---|
| iDNA | 10 | 10–320 (40.2)c | 105 PFU | 5/10 (50%) | 0.9–3.8 | 10/10 (100%) |
| Mock | 5 | <10 | 105 PFU | 5/5 (100%) | 4.3–5.0 | 0/5 (0%) |
a
Challenge was done with 1×105 408 PFU in 100 µl of VEE-3908 virus.
b
Day 1 post-challenge.
c
In unrelated experiment in BALB/c mice, TC-83 vaccination resulted in the PRNT80 titer of 1:640.