Skip to main content
NCBI home page
Journal of Virology logoLink to Journal of Virology
. 1974 Nov;14(5):1126–1131. doi: 10.1128/jvi.14.5.1126-1131.1974

Cell Surface Antigen Induced by Friend Murine Leukemia Virus Is also in the Virion

Maureen Friedman 1, Frank Lilly 1, Stanley G Nathenson 1
PMCID: PMC355629  PMID: 4431079

Abstract

Intact particles of Friend leukemia virus derived from infectious mouse serum absorb only trace amounts of cytotoxic anti-FMR antibodies, but physical disruption of the virions by freezing and thawing, by ether extraction or by detergent treatment releases large amounts of FMR antigenic activity. Thus this antigen, previously considered to occur mainly as a neo-antigen on the surfaces of virus-infected cells and as a soluble substance in the serum of infected mice, may be primarily a virion component.

Full text

PDF
1126

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cohen M. H., Sibal L. R., Fink M. A. Relative importance of viral and neoantigens in cytotoxic reaction against murine leukaemia cells. Immunology. 1974 Jan;26(1):37–48. [PMC free article] [PubMed] [Google Scholar]
  2. DE HARVEN E., FRIEND C. Further electron microscope studies of a mouse leukemia induced by cell-free filtrates. J Biophys Biochem Cytol. 1960 Jul;7:747–752. doi: 10.1083/jcb.7.4.747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hartley J. W., Rowe W. P., Huebner R. J. Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures. J Virol. 1970 Feb;5(2):221–225. doi: 10.1128/jvi.5.2.221-225.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Larsen C. J., Emanoil-Ravicovitch R., Samso A., Robin J., Tavitian A., Boiron M. Presence of two "8 S" RNA components in mouse sarcoma virus (Moloney). Virology. 1973 Aug;54(2):552–556. doi: 10.1016/0042-6822(73)90167-0. [DOI] [PubMed] [Google Scholar]
  5. Lilly F., Nathenson S. G. Studies on the FMR antigen. Transplant Proc. 1969 Mar;1(1):85–89. [PubMed] [Google Scholar]
  6. Nathenson S. G., Davies D. A. Solubilization and partial purification of mouse histocompatibility antigens from a membranous lipoprotein fraction. Proc Natl Acad Sci U S A. 1966 Aug;56(2):476–483. doi: 10.1073/pnas.56.2.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. OLD L., BOYSE E. A., LILLY F. FORMATION OF CYTOXIC ANTIBODY AGAINST LEUKEMIAS INDUCED BY FRIEND VIRUS. Cancer Res. 1963 Aug;23:1063–1068. [PubMed] [Google Scholar]
  8. Old L. J., Boyse E. A. Antigens of tumors and leukemias induced by viruses. Fed Proc. 1965 Sep-Oct;24(5):1009–1017. [PubMed] [Google Scholar]
  9. STUECK B., OLD L. J., BOYSE E. A. OCCURRENCE OF SOLUBLE ANTIGEN IN THE PLASMA OF MICE WITH VIRUS-INDUCED LEUKEMIA. Proc Natl Acad Sci U S A. 1964 Oct;52:950–958. doi: 10.1073/pnas.52.4.950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Shimada A., Nathenson S. G. Murine histocompatibility-2 (H-2) alloantigens. Purification and some chemical properties of soluble products from H-2b and H-2d genotypes released by papain digestion of membrane fractions. Biochemistry. 1969 Oct;8(10):4048–4062. doi: 10.1021/bi00838a023. [DOI] [PubMed] [Google Scholar]
  11. Steeves R. A. Cellular antigen of Friend virus-induced leukemias. Cancer Res. 1968 Feb;28(2):338–342. [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES