Abstract
Nine virulent bacteriophages of the anaerobe Corynebacterium (Propionibacterium) acnes, the P-a series, are DNA phages, with long, curved nonretractile tails (130 nm) without tail plates or fibers. They have isometric heads (420 by 460 nm), and are placed in Bradley's group B-1. There is permanent plaque suppression at highest phage concentrations. After 100- to 1,000-fold dilution, plaques are evident. The latent period is 1 h and burst size 25. Cross-neutralization data of antisera for the nine phages are similar. There is an unexplained precipitous drop in plaque-forming units during the first 5 min of neutralization, after which the rate is linear for 2 h. They are sensitive to pH extremes but are partially protected even at pH 4 or 9 by storage at 4 C. They are resistant to ether and chloroform and are inactivated within 10 min at 70 C.
Full text
PDF





Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Balfour H. H., Jr, Minken S. L. Liver abscess due to corynebacterium acnes. Diphtheroid as pathogen. Clin Pediatr (Phila) 1971 Jan;10(1):55–58. doi: 10.1177/000992287101000119. [DOI] [PubMed] [Google Scholar]
- Bradley D. E. The fluorescent staining of bacteriophage nucleic acids. J Gen Microbiol. 1966 Sep;44(3):383–391. doi: 10.1099/00221287-44-3-383. [DOI] [PubMed] [Google Scholar]
- Bradley D. E. Ultrastructure of bacteriophage and bacteriocins. Bacteriol Rev. 1967 Dec;31(4):230–314. doi: 10.1128/br.31.4.230-314.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KIRSCHBAUM J. O., KLIGMAN A. M. THE PATHOGENIC ROLE OF CORYNEBACTERIUM ACNES IN ACNE VULGARIS. Arch Dermatol. 1963 Dec;88:832–833. doi: 10.1001/archderm.1963.01590240156026. [DOI] [PubMed] [Google Scholar]
- PREVOT A. R., THOUVENOT H. [Attempted phage-typing of anaerobic Corynebacteria]. Ann Inst Pasteur (Paris) 1961 Dec;101:966–970. [PubMed] [Google Scholar]
- Reid J. D., Greenwood L. Corynebacterial endocarditis. A report of two cases with review. Arch Intern Med. 1967 Jan;119(1):106–110. doi: 10.1001/archinte.119.1.106. [DOI] [PubMed] [Google Scholar]