Abstract
Analysis of serial sections of murine cells containing intracisternal A particles revealed that over 99% of all A particles remain in a budding configuration. This indicates that these particles fail to detach from the membrane of the endoplasmic reticulum. This observation explains how, despite their intracellular abundance in certain murine tumors, no extracellular A-type particles can be found.
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- BERNHARD W. The detection and study of tumor viruses with the electron microscope. Cancer Res. 1960 Jun;20:712–727. [PubMed] [Google Scholar]
- DALTON A. J., POTTER M., MERWIN R. M. Some ultrastructural characteristics of a series of primary and transplanted plasma-cell tumors of the mouse. J Natl Cancer Inst. 1961 May;26:1221–1267. [PubMed] [Google Scholar]
- Hall W. T., Hartley J. W., Sanford K. K. Characteristics of and relationship between C particles and intracisternal A particles in cloned cell strains. J Virol. 1968 Mar;2(3):238–247. doi: 10.1128/jvi.2.3.238-247.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kimura I., Miyake T., Ishimoto A., Ito Y. Intracisternal A-type and C-type particles observed in pulmonary tumors in mice. Gan. 1972 Oct;63(5):563–573. [PubMed] [Google Scholar]
- Kodama T., Kodama M. Correlation between tumor invasiveness and content of A-type particles in Ehrlich ascites tumor: a model of quantitative electron microscopy. J Natl Cancer Inst. 1973 Mar;50(3):707–712. doi: 10.1093/jnci/50.3.707. [DOI] [PubMed] [Google Scholar]
- Kuff E. L., Leuders K. K., Ozer H. L., Wivel N. A. Some structural and antigenic properties of intracisternal A particles occurring in mouse tumors (complement fixation-immunodiffusion-neuroblastoma-plasma-cell tumor). Proc Natl Acad Sci U S A. 1972 Jan;69(1):218–222. doi: 10.1073/pnas.69.1.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kuff E. L., Wivel N. A., Lueders K. K. The extraction of intracisternal A-particles from a mouse plasma-cell tumor. Cancer Res. 1968 Oct;28(10):2137–2148. [PubMed] [Google Scholar]
- Nadel E., Banfield W., Burstein S., Tousimis A. J. Virus particles associated with strain 2 guinea pig leukemia (L2C/N-B). J Natl Cancer Inst. 1967 Jun;38(6):979–981. [PubMed] [Google Scholar]
- Perk K., Hod I., Nobel T. A. Pulmonary adenomatosis of sheep (jaagsiekte). I. Ultrastructure of the tumor. J Natl Cancer Inst. 1971 Mar;46(3):525–537. [PubMed] [Google Scholar]
- Stewart S. E., Kasnic G., Jr, Draycott C., Ben T. Activation of viruses in human tumors by 5-iododeoxyuridine and dimethyl sulfoxide. Science. 1972 Jan 14;175(4018):198–199. doi: 10.1126/science.175.4018.198. [DOI] [PubMed] [Google Scholar]
- Tumilowicz J. J., Cholon J. J. Intracisternal type A particles and properties of a continuous cell line originating from a gerbil fibroma. Proc Soc Exp Biol Med. 1971 Apr;136(4):1107–1110. doi: 10.3181/00379727-136-35439. [DOI] [PubMed] [Google Scholar]
- Wilson S. H., Kuff E. L. A novel DNA polymerase activity found in association with intracisternal A-type particles. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1531–1536. doi: 10.1073/pnas.69.6.1531. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wivel N. A., Smith G. H. Distribution of intracisternal A-particles in a variety of normal and neoplastic mouse tissues. Int J Cancer. 1971 Jan 15;7(1):167–175. doi: 10.1002/ijc.2910070119. [DOI] [PubMed] [Google Scholar]
- Yang S. S., Wivel N. A. Analysis of high-molecular-weight ribonucleic acid associated with intracisternal A particles. J Virol. 1973 Feb;11(2):287–298. doi: 10.1128/jvi.11.2.287-298.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yang S. S., Wivel N. A. Characterization of an endogenous RNA-dependent DNA polymerase associated with murine intracisternal A particles. J Virol. 1974 Mar;13(3):712–720. doi: 10.1128/jvi.13.3.712-720.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]